Details:

Alternative Title:
Prev Chronic Dis
Personal Author:
García-Bailo, Bibiana ; Da Costa, Laura A. ; Arora, Paul ; Karmali, Mohamed ; El-Sohemy, Ahmed ; ... More +
García-Bailo, Bibiana ; Da Costa, Laura A. ; Arora, Paul ; Karmali, Mohamed ; El-Sohemy, Ahmed ; Badawi, Alaa Less -
Description:
Introduction

Vitamin D may modulate cardiometabolic disease risk, although the relationship has not been investigated in the general Canadian population. Understanding this relationship may inform public health strategies to curb the incidence of cardiometabolic disease in Canada and elsewhere. The objectives of this study were to examine the association between vitamin D and traditional and novel biomarkers of cardiometabolic disease and to describe the extent of the month-to-month fluctuations of vitamin D in the Canadian population.

Methods

We examined the association between plasma 25-hydroxyvitamin D and a range of cardiometabolic risk biomarkers in participants (n = 1,928; age range, 16–79 years) from the Canadian Health Measures Survey. We conducted linear regressions analyses (adjusted for sex, waist circumference, physical activity, hormone use, and season) to assess the relationship between 25-hydroxyvitamin D and biomarkers of dysglycemia, dyslipidemia, and inflammation in the study population. We repeated analyses stratified by sex, and we evaluated monthly fluctuations in 25-hydroxyvitamin D in men and women.

Results

We observed wide month-to-month variations in 25-hydroxyvitamin D; fluctuations were more pronounced in men. Plasma 25-hydroxyvitamin D was inversely associated with insulin, insulin resistance, triglycerides, total cholesterol, low-density lipoprotein cholesterol, and the ratio of total to high-density lipoprotein cholesterol but not with fasting glucose, apolipoprotein A1, apolipoprotein B, C-reactive protein, fibrinogen, or homocysteine. This pattern varied between men and women.

Conclusion

Vitamin D may modulate various metabolic processes and may influence cardiometabolic disease risk in Canadians. These findings may have public health implications when recommending vitamin D for the prevention of cardiometabolic disease and related conditions.


Subjects:
[+]
Adolescent Adult Aged Anthropometry Biological Markers Cardiovascular Diseases Exercise Female Humans Linear Models Male Metabolic Syndrome X Middle Aged Risk Assessment Risk Factors Sex Factors Vitamin D Young Adult
Source:
Prev Chronic Dis. 10.
Document Type:
Journal Article
Place as Subject:
Canada
Location:
North America
Collection(s):
Preventing Chronic Disease
Main Document Checksum:
[+]
urn:sha256:d2ca74e55c16d760157f895cd2e7cf9963e76e4d9f2364607eb13e8ccc975d7b
Download URL:
https://stacks.cdc.gov/view/cdc/22168/cdc_22168_DS1.pdf
File Type:

Supporting Files

• 	license.txt	txt
  	PCD-10-E91.nxml	txt
  	PCD-10-E91s01.gif	gif
  	PCD-10-E91s01.jpg	jpeg

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