Occupational Livestock or Animal Dust Exposure and Offspring Cancer Risk in Denmark, 1968–2016

Details

• Personal Author:
  Hall C ; Hansen J ; He D ; Heck JE ; Olsen J ; Ritz B ; von Ehrenstein OS
• Description:
  Objective: To examine associations with occupational livestock or other animal dust exposure and offspring cancer risk. Methods: In this population-based case-control study of Danish children aged < 17 years old, 5078 childhood cancer cases diagnosed 1968-2016 were matched to cancer-free controls by birth year and sex (n = 123,228). Occupational livestock or animal dust exposure was identified using a job-exposure matrix. We employed multivariable conditional logistic regression models to estimate associations with offspring cancer for births 1968-2016 and 1989-2016, with the latter timeframe reflecting a period of presumed higher exposure due to changes in Danish farming practices. Sensitivity analyses considered place of birth (urban areas vs. rural areas and small towns). Results: For births 1968-2016, paternal exposure from offspring birth to cancer diagnosis was associated with central nervous system tumors (adjusted odds ratio [OR] = 1.30, 95% confidence interval [CI] 1.04-1.63) and germ cell tumors (OR = 1.82, 95% CI 1.05-3.27), while maternal pregnancy exposure was associated with astrocytoma (OR = 1.89, 95% CI 1.00-3.57). For births 1989-2016, paternal exposure from offspring birth to cancer diagnosis was negatively associated with acute lymphoid leukemia (OR = 0.58, 95% CI 0.33-1.00). For births in rural areas only, maternal exposure from offspring birth to cancer diagnosis was positively associated with acute myeloid leukemia (OR = 2.16, 95% CI 1.09-4.29). Conclusions: This study suggests that paternal occupational animal exposure is associated with offspring germ cell tumors, and maternal pregnancy exposure with astrocytomas. Our results are mixed with respect to leukemia subtypes. [Description provided by NIOSH]
• Subjects:
  Animals Dust Epidemiology Livestock Neoplasms Occupational Health Safety
• Keywords:
  Author Keywords: Childhood Cancer Cancer Rates Central Nervous System Disorders Central Nervous System Tumor Dust Exposure Dusts Germ Cell Tumor Job-exposure Matrix Leukemia Livestock Industry Tumors

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• ISSN:
  0340-0131
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  93
• Issue:
  5
• NIOSHTIC Number:
  nn:20058569
• Citation:
  Int Arch Occup Environ Health 2020 Jul; 93(5):659-668
• Contact Point Address:
  Julia E. Heck, Department of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, Los Angeles, CA
• Email:
  jeheck@ucla.edu
• Federal Fiscal Year:
  2020
• Performing Organization:
  University of California Los Angeles
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  International Archives of Occupational and Environmental Health
• End Date:
  20270630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:2d74c836a57e5549fcee8b2570be841d4e441236176ebb469e6f50fd0a46891f564f5dcbd09b53dbe17512fe0f581d59170d0979ed2cb78d29e052663833d965
• Download URL:
  https://stacks.cdc.gov/view/cdc/221632/cdc_221632_DS1.pdf
• File Type:
  [PDF - 567.06 KB ]