Filling a Hole in Ozone Research: The Impacts of Early Life Microbiome Alterations on Pulmonary Responses to a Non-Atopic Asthma Trigger

Details

• Personal Author:
  Belenky P ; Johnston RA
• Description:
  The predominantly commensal collection of bacteria, fungi, archaea, protozoa, and viruses that inhabit multicellular organisms constitutes the microbiota, and their DNA is referred to as the microbiome. Early-life microbiome perturbation influences the development of asthma (Russell et al., (2012)), which is a chronic lung disease that is characterized, in part, by persistent lung inflammation, cough, dyspnea, wheeze, variable expiratory flow limitation, and airway hyperresponsiveness (AHR). As a heterogeneous lung disease, asthma materializes as a diverse number of clinical phenotypes that result from exposure to either atopic or nonatopic stimuli (Wenzel, 2012). Russell et al. (2012) demonstrated that the magnitude of atopic lung inflammation induced by antigen (ovalbumin) sensitization and challenge in an animal model, which mimics features of atopic asthma in humans, is dependent upon the age when the gastrointestinal microbiota is perturbed. For example, administration of vancomycin, a glycopeptide antibiotic, to neonatal mice exacerbated antigen-induced lung inflammation that was assessed by enumerating the number of bronchoalveolar lavage (BAL) eosinophils. However, dosing adult mice with vancomycin did not exacerbate lung inflammation. Russell et al. (2012) proposed that heterogeneity in antigen-induced lung inflammation between vancomycin- treated mice of different ages was associated with differences in the composition of the gut microbiota yet did not present any extensive data to provide a mechanism for this phenomenon. [Description provided by NIOSH]
• Subjects:
  Age Factors Animals Asthma Fungi Laboratories Lung Lung Diseases Microbiology Occupational Health Ozone Respiratory System Respiratory Tract Diseases Safety Viral Diseases

  More +
• Keywords:
  Age Factors Bacteria Bronchial Asthma Laboratory Animals Lung Disease Models Pulmonary Effects Pulmonary System Pulmonary System Disorders Viral Diseases
• ISSN:
  2051-817X
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 1 ; OSHA Region 3 ; Rhode Island ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  8
• Issue:
  1
• NIOSHTIC Number:
  nn:20058496
• Citation:
  Physiol Rep 2020 Jan; 8(1):e14346
• Contact Point Address:
  Richard A. Johnston, Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia
• Email:
  rfj1@cdc.gov
• CAS Registry Number:
  Ozone (CAS RN 10028-15-6)
• Federal Fiscal Year:
  2020
• NORA Priority Area:
  Manufacturing
• Peer Reviewed:
  False
• Source Full Name:
  Physiological Reports
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:4962354a90e48ffca970f18b5b0c5e5c19b79848a29adc526052e1ac7e197b23b605ce4d61ee034c692daf1dfe17530bfcc3f1625a92fe90bc19e7fbaf8c5d31
• Download URL:
  https://stacks.cdc.gov/view/cdc/221581/cdc_221581_DS1.pdf
• File Type:
  [PDF - 203.83 KB ]