Evidence for Excess Colorectal Cancer Incidence Among Asbestos-Exposed Men in the Beta-Carotene and Retinol Efficacy Trial

Details

• Personal Author:
  Aliyu OA ; Balmes JR ; Barnett MJ ; Barnhart S ; Brodkin CA ; Cartmel B ; Cullen MR ; Goodman GE ; Israel L ; Omenn GS ; Redlich CA ; Rosenstock, Linda ; Thornquist MD
• Description:
  The relation between asbestos exposure and colorectal cancer remains controversial. The authors of this 1984-2004 US study examined the association among 3,897 occupationally exposed participants in the Beta-Carotene and Retinol Efficacy Trial (CARET) for chemoprevention of lung cancer, followed prospectively for 10-18 years. When a Cox stratified proportional hazards model was used, risks of colorectal cancer were elevated among male heavy smokers exposed to asbestos. Their relative risk was 1.36 (95% confidence interval: 0.96, 1.93) when compared with that for CARET heavy smokers not exposed to asbestos, after adjusting for age, smoking history, and intervention arm. The presence of asbestos-induced pleural plaques at baseline was associated with a relative risk of 1.54 (95% confidence interval: 0.99, 2.40); colorectal cancer risk also increased with worsening pulmonary asbestosis (p = 0.03 for trend). A dose-response trend based on years of asbestos exposure was less evident. Nonetheless, these data suggest that colorectal cancer risk is elevated among men occupationally exposed to asbestos, especially those with evidence of nonmalignant asbestos-associated radiographic changes. [Description provided by NIOSH]
• Subjects:
  Age Factors Asbestos Epidemiology Inorganic Chemicals Men Neoplasms Occupational Exposure Occupational Health Safety Smokers
• Keywords:
  Age Factors Asbestosis Author Keywords: Asbestos Cancer Rates Colorectal Cancer Colorectal Neoplasms Environmental Exposure Occupational Exposure Prospective Studies Randomized Controlled Trials Smoking

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• ISSN:
  0002-9262
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; Connecticut ; Michigan ; OSHA Region 1 ; OSHA Region 10 ; OSHA Region 5 ; OSHA Region 9 ; Washington
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  162
• Issue:
  9
• NIOSHTIC Number:
  nn:20058428
• Citation:
  Am J Epidemiol 2005 Nov; 162(9):868-878
• Contact Point Address:
  Dr. Mark R. Cullen, 135 College Street, New Haven, CT 06510
• Email:
  mark.cullen@yale.edu
• CAS Registry Number:
  Asbestos (CAS RN 1332-21-4)
• Federal Fiscal Year:
  2006
• Performing Organization:
  University of California Los Angeles
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  American Journal of Epidemiology
• End Date:
  20270630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:141704248b10739e2284f595ef4c7ef91a87e9cd47fb50f5501bc766de0650fd61ab00813a42e63c044aa22c453b56cc7a0f397ef4d87ca9f216c3a5e3366115
• Download URL:
  https://stacks.cdc.gov/view/cdc/221520/cdc_221520_DS1.pdf
• File Type:
  [PDF - 154.47 KB ]