Effect of Lifestyle Exposures on Sperm Aneuploidy

Details

• Personal Author:
  Elashoff DA ; Jia J ; Li N ; Robbins WA ; Wei F ; Wu G ; Xun L
• Description:
  Lifestyle exposures including cigarette smoke, alcohol, and caffeine have all been studied in relationship to male reproductive health. Over the years the focus has primarily been on semen quality and/or fertility. More recently, literature evaluating direct adverse effects of lifestyle exposures on sperm chromosomes and chromatin has grown due to concern that induced damage could be transmitted to offspring causing transgenerational health effects. In this paper we present a new analysis that summarizes published studies of smoking effects on sperm chromosome number and demonstrates a statistically significant increase in sperm disomy among smokers compared to nonsmokers (P < 0.001). In addition, new data on the effect of alcohol intake on sperm chromosome number are presented showing a rate ratio of 1.38 (95% CI 1.2, 1.6) for XY frequency in sperm of alcohol drinkers compared to nondrinkers. [Description provided by NIOSH]
• Subjects:
  Alcoholic Beverages Chromosomes Genetics Occupational Health Safety Smokers Tobacco Products Urogenital System
• Keywords:
  Alcohol Alcoholic Beverages Chromosome Damage Cigarette Smoking Reproductive Effects Reproductive Hazards Spermatozoa
• ISSN:
  1424-8581
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  371-377
• Volume:
  111
• Issue:
  3
• NIOSHTIC Number:
  nn:20058424
• Citation:
  Cytogenet Genome Res 2005 Sep; 111(3-4):371-377
• Contact Point Address:
  Wendie A. Robbins, PhD, UCLA Center for Occupational and Environmental, Health Room 5-254 Factor Building, Mailcode 956919, University of California Los Angles 90095-6919 CA
• Email:
  wrobbins@sonnet.ucla.edu
• CAS Registry Number:
  Boron (CAS RN 7440-42-8)
• Federal Fiscal Year:
  2005
• Performing Organization:
  University of California, Los Angeles
• Peer Reviewed:
  True
• Start Date:
  20010930
• Source Full Name:
  Cytogenetic and Genome Research
• End Date:
  20070929
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:08f9891b6bb45e5450082bf0c1ea3d721bcc0413f423b949e7766bd30fc1d534890d245670b3813fb41d0ec081774946ea4b8a03b50347ff22e2c053bfab8b07
• Download URL:
  https://stacks.cdc.gov/view/cdc/221517/cdc_221517_DS1.pdf
• File Type:
  [PDF - 125.48 KB ]