Impact of Occupational Exposure on Human Microbiota

Details

• Personal Author:
  Christiani, David C. ; Lai PS
• Description:
  Purpose of review: Recent evidence suggests that environmental exposures change the adult human microbiome. Here, we review recent evidence on the impact of the work microbiome and work-related chemical, metal and particulate exposures on the human microbiome. Recent findings: Prior literature on occupational microbial exposures has focused mainly on the respiratory effects of endotoxin, but a recent study suggests that not all endotoxin is the same; endotoxin from some species is proinflammatory, whereas endotoxin from other species is anti-inflammatory. Work with animals can change the adult human microbiome, likely through colonization. Early studies in military personnel and animal models of gulf war illness show that military exposures change the gut microbiome and increase gut permeability. Heavy metal and particulate matter exposure, which are often elevated in occupational settings, also change the gut microbiome. Summary: An emerging body of literature shows that work-related exposures can change the human microbiome. The health effects of these changes are currently not well studied. If work exposures lead to disease through alterations in the human microbiome, exposure cessation without addressing changes to the human microbiome may be ineffective for disease prevention and treatment. [Description provided by NIOSH]
• Subjects:
  Asthma, Occupational Microbiology Occupational Exposure Occupational Health Safety Workplace
• Keywords:
  Asthma Author Keywords: Microbiome Biological Effects Humans Occupational Occupational Asthma Occupational Exposure Work Work Environment
• ISSN:
  1528-4050
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Massachusetts ; OSHA Region 1 ; OSHA Region 4 ; South Carolina
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  86-91
• Volume:
  19
• Issue:
  2
• NIOSHTIC Number:
  nn:20058353
• Citation:
  Curr Opin Allergy Clin Immunol 2019 Apr; 19(2):86-91
• Contact Point Address:
  Peggy S. Lai, MD, MPH, Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, 55 Fruit Street, Bulfinch 148, Boston, MA 02114, USA
• Email:
  pslai@hsph.harvard.edu
• Federal Fiscal Year:
  2019
• Performing Organization:
  Harvard School of Public Health
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Current Opinion in Allergy and Clinical Immunology
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:fd99f7857ee83c016a0e9e2119d9828aacbd4b69732a2608dc7d02002023c569dc80d83d0f2cce22eb1d7b84eac66fdfb0bf3f53d3be0d67f27a850c74f65a4f
• Download URL:
  https://stacks.cdc.gov/view/cdc/221469/cdc_221469_DS1.pdf
• File Type:
  [PDF - 243.04 KB ]