Prenatal Beta-Hexachlorocyclohexane (Beta-HCH) Exposure and 7-Year Child IQ in the CHAMACOS Birth Cohort

Details

• Personal Author:
  Eskenazi B ; Harley K ; Kogut K ; Kokroko J
• Description:
  Fetal and infant exposures to beta-hexachlorocyclohexane (beta-HCH) occur through placental and breastmilk transfers. No studies have examined the relationship between beta-HCH and child intelligence quotient (IQ). This study examined associations between in utero beta-HCH exposure and cognitive development in 7-year-old children. Data from women and children (n = 256) participating in the Center for the Health Assessment of Mothers and Children of Salinas (CHAMACOS) birth cohort study were evaluated. We assessed exposure to beta-HCH by measuring maternal serum concentration during pregnancy. We administered the Wechsler Intelligence Scale for Children (WISC), Fourth Edition, to children at age 7. Analyses were adjusted for maternal age, country of birth, work status, parity, and other pesticide exposures, language used for child cognitive assessment, and duration of breastfeeding. Higher serum beta-HCH concentrations were associated with higher cognitive scores across all unadjusted models for the full-scale and sub-scale cognitive tests. In the adjusted models, a 10-fold increase in serum beta-HCH concentration was associated with a 4.5-point increase in Working Memory IQ score (95% CI, 0.6 to 8.3; p = 0.02). We observed no significant interaction by length of breastfeeding or sex on associations. Our findings suggest that prenatal exposure to beta-HCH is not adversely related to IQ at age 7 in a cohort of Mexican American children with fairly high exposure in utero as measured by maternal serum levels. Future research must replicate these findings in other study cohorts of women and children. [Description provided by NIOSH]
• Subjects:
  Aging Demography Environmental Exposure Family Insecticides Nervous System Occupational Health Pregnancy Risk Assessment Risk Factors Safety Women

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• Keywords:
  Age Groups Author Keywords: Beta-Hexachlorocyclohexane Children Cognitive Development Cognitive Function Demographic Characteristics Exposure Levels Families Humans In Utero Exposure Models Neurodevelopment Neurological System Organic Chemicals Organic Compounds Organochlorine Compounds Organochlorine Pesticide Pesticides Pesticides And Agricultural Chemicals Prenatal Exposure Risk Factors Workers

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• ISSN:
  1029-8428
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  37
• Issue:
  3
• NIOSHTIC Number:
  nn:20058344
• Citation:
  Neurotox Res 2020 Mar; 37(3):553-563
• Contact Point Address:
  Jolene Kokroko, School of Medicine, University of California San Francisco, San Francisco, USA
• Email:
  jolene.kokroko@ucsf.edu
• CAS Registry Number:
  β-Hexachlorocyclohexane (CAS RN 319-85-7)
• Federal Fiscal Year:
  2020
• Performing Organization:
  University of California, Berkeley
• Peer Reviewed:
  True
• Start Date:
  20010930
• Source Full Name:
  Neurotoxicity Research
• End Date:
  20060929
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:eee8968f931b6a9544a4a2329401aff23b9d8f484ba9c4709e435bc9e43c78aae738aa7dda1cacba27434d10b3b45791bb794576fb8fe85920f54ac7e70e96b9
• Download URL:
  https://stacks.cdc.gov/view/cdc/221463/cdc_221463_DS1.pdf
• File Type:
  [PDF - 370.75 KB ]