Methods for Modeling Particle Deposition as a Function of Age

Details

• Personal Author:
  Oldham MJ ; Phalen RF
• Description:
  The purpose of this paper is to review the application of mathematical models of inhaled particle deposition to people of various ages. The basic considerations of aerosol physics, biological characteristics and model structure are presented along with limitations inherent in modern modeling techniques. Application of the models to children and senescent adults has been largely based on extrapolating anatomical and physiological data from young adults to match the changes observed during growth and aging. Sample results are included for total particle deposition and deposition in the bronchial and pulmonary regions. The models proposed provide particle deposition predictions that are consistent with the scant measurements available. The models discussed appear to be on firm theoretical grounds, but they are largely limited in application to simple aerosols and average individuals. Also, additional validation of the computational predictions is needed. [Description provided by NIOSH]
• Subjects:
  Aerosols Age Factors Occupational Health Safety
• Keywords:
  Aerosol Particles Age Factors Airways Author Keywords: Airways Children Development Humans Mammals Mathematical Models Model Particle Deposition Physiological Factors Senescent Adult

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• ISSN:
  0034-5687
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  119-130
• Volume:
  128
• Issue:
  1
• NIOSHTIC Number:
  nn:20058209
• Citation:
  Respir Physiol 2001 Oct; 128(1):119-130
• Contact Point Address:
  Robert F. Phalen, Community and Environmental Medicine, Air Pollution Health Effects Laboratory, University of California, Irvine, CA 92697-1825, USA
• Email:
  rfphalen@uci.edu
• Federal Fiscal Year:
  2002
• Performing Organization:
  University of California, School of Public Health, Los Angeles, CA
• Peer Reviewed:
  True
• Start Date:
  19990701
• Source Full Name:
  Respiration Physiology
• End Date:
  20040630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:3225c0a898fc6ec134430a6f50b56c439327c9280246e895422253758133160dd31a26ebab4eafa93ecf8379532626d7d89fd66b641d85843db4978f3bb8911c
• Download URL:
  https://stacks.cdc.gov/view/cdc/221343/cdc_221343_DS1.pdf
• File Type:
  [PDF - 141.15 KB ]