Use of Benchmark Dose Models in Risk Assessment for Occupational Handlers of Eight Pesticides Used in Pome Fruit Production

Details

• Personal Author:
  Cullen AC ; Fenske RA ; Gurnick Pouzou J ; Kissel J ; Yost MG
• Description:
  The benchmark dose has been frequently recommended for the creation of points of departure for regulatory dose limits, but many regulations, including pesticide risk assessment and registration in the United States, continues to rely on NOAEL methods as the OECD toxicological standard methods recommend. This study used data from studies in support of pesticide registration for eight different compounds to build dose-response models and calculate benchmark doses and confidence limits. The results were compared to the NOAEL of the same study. A probabilistic estimate of dose was compared with all points of departure to demonstrate differences in the protective ability of each different selected limit. While neither the BMD/BMDL nor the NOAEL was consistently more protective, the advantage of using the BMD in quantifying the uncertainty of the point of departure is highlighted, and the feasibility of using current OECD-guideline studies for derivation of a BMD is demonstrated in these cases. [Description provided by NIOSH]
• Subjects:
  Insecticides Occupational Exposure Occupational Health Risk Assessment Safety Toxicology
• Keywords:
  Author Keywords: Benchmark Dose Modeling Dose Response Exposure Assessment Exposure Limits Guidelines Margin Of Exposure Models NOAEL Occupational Exposure Pesticides Recommendations Regulations Risk Analysis Standards

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• ISSN:
  RTOPDW
• Document Type:
  Text
• Funding:
  Cooperative Agreement ; Grant
• Genre:
  Journal Article
• Place as Subject:
  Colorado ; OSHA Region 10 ; OSHA Region 8 ; Washington
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  110
• NIOSHTIC Number:
  nn:20058203
• Citation:
  Regul Toxicol Pharmacol 2020 Feb; 110:104504
• Contact Point Address:
  Jane Gurnick Pouzou, EpiX Analytics, LLC, United States
• Email:
  jpouzou@epixanalytics.com
• Federal Fiscal Year:
  2020
• NORA Priority Area:
  Agriculture, Forestry and Fishing
• Performing Organization:
  University of Washington
• Peer Reviewed:
  True
• Start Date:
  20010930
• Source Full Name:
  Regulatory Toxicology and Pharmacology
• End Date:
  20270929
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:2b8c6ef88a4927b2af99eef7c5414c26896dd83340bdc0c3cc67e43bfcce211ca0577de49a8de706a13cf4e685790d1ee8ad8af42b4663dcc2d524ccb1e60838
• Download URL:
  https://stacks.cdc.gov/view/cdc/221338/cdc_221338_DS1.pdf
• File Type:
  [PDF - 710.93 KB ]