Computational Fluid Dynamic Predictions and Experimental Results for Particle Deposition in an Airway Model

Details

• Personal Author:
  Heistracher T ; Oldham MJ ; Phalen RF
• Description:
  An area identified as having a high priority by the National Research Council (NRC 1998) relating to health effects of exposure to urban particulate matter is the investigation of particle deposition patterns in potentially-susceptible subpopulations. A key task for risk assessment is development and refinement of mathematical models that predict local deposition patterns of inhaled particles in airways. Recently, computational fluid dynamic modeling (CFD) has provided the ability to predict local airflows and particle deposition patterns in various structures of the human respiratory tract. Although CFD results generally agree with available data from human studies, there is a need for experimental particle deposition investigations that provide more detailed comparisons with computed local patterns of particle deposition. Idealized 3-generation hollow tracheo-bronchial models based on the Weibel symmetric morphometry for airway lengths and diameters (generations 3-5) were constructed with physiologically-realistic bifurcations. Monodisperse fluorescent polystyrene latex particles (1 and 10 mu m aerodynamic diameter) were deposited in these models at a steady inspiratory flow of 7.5 L /min (equivalent to heavy exertion with a tracheal flow of 60 L /min). The models were opened and the locations of deposited particles were mapped using fluorescence microscopy. The particle deposition predictions using CFD for 10 mu m particles correlated well with those found experimentally. CFD predictions were not available for the 1 mu m diameter case, but the experimental results for such particles are presented. [Description provided by NIOSH]
• Subjects:
  Aerosols Air Pollution Occupational Health Particulate Matter Respiratory System Safety Software Toxicology
• Keywords:
  Aerosol Particles Air Pollution Airway Resistance Computer Models Inhalation Studies Particulates Respiratory Function
• ISSN:
  0278-6826
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  61-71
• Volume:
  32
• Issue:
  1
• NIOSHTIC Number:
  nn:20058198
• Citation:
  Aerosol Sci Technol 2000 Jan; 32(1):61-71
• Contact Point Address:
  Michael J. Oldham, Air Pollution Health Effects Laboratory, Department of Community and Environmental Medicine, University of California, Irvine, CA 92697-1825
• Federal Fiscal Year:
  2000
• Performing Organization:
  University of California, School of Public Health, Los Angeles, CA
• Peer Reviewed:
  True
• Start Date:
  19990701
• Source Full Name:
  Aerosol Science and Technology
• End Date:
  20040630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:47e0cf38dfb752dac782ddf610eac654f08ac7c4b425745e748dfb8b897f9f77ea07f1afa100e1e91adb696e9200a0418c9d64656e1fb35b0d61a1fdcab99d23
• Download URL:
  https://stacks.cdc.gov/view/cdc/221333/cdc_221333_DS1.pdf
• File Type:
  [PDF - 585.19 KB ]