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Modulation of Oxidative Events by Multivalent Manganese Complexes in Brain Tissue



Details

  • Personal Author:
  • Description:
    Manganese toxicity can evoke neuropsychiatric and neuromotor symptoms, which have frequently been attributed to profound oxidative stress in the dopaminergic system. However, the characterization of manganese as a pro-oxidant remains controversial because antioxidant properties also have been associated with this metal. The current study was designed to address these disparate findings concerning the oxidative properties of manganese. The apparent ability of manganese in its divalent form to promote formation of reactive oxygen species (ROS) within a cortical mitochondrial-synaptosomal (P2) fraction was completely abolished by the addition of one five hundredth of its molarity of desferroxamine (DFO), a trivalent metal chelator. This large ratio and the high specificity of DFO for trivalent metal ions discounted the possibility of inhibition of ROS generation by direct sequestration of divalent manganese, and implied the trace presence of a trivalent metal. Further analysis suggested that this trace metal was manganic rather than ferric ion. Ferric ion was able to dampen the reactive oxygen species-generating capacity of manganous chloride, whereas manganic ion markedly promoted this property attributed to manganous ion. Such findings of the potent effects of trace amounts of trivalent cations upon Mn2+-related free radical generation offer resolution of earlier disparate findings concerning the oxidative character of manganese. [Description provided by NIOSH]
  • Subjects:
  • Keywords:
  • ISSN:
    0891-5849
  • Document Type:
    Text
  • Funding:
    Grant
  • Genre:
    Journal Article
  • Place as Subject:
  • CIO:
    National Institute for Occupational Safety and Health (NIOSH)
  • Topic:
    Workplace Safety & Health
  • Location:
    North America
  • Volume:
    31
  • Issue:
    6
  • NIOSHTIC Number:
    nn:20058153
  • Citation:
    Free Radic Biol Med 2001 Sep; 31(6):763-768
  • Contact Point Address:
    Dr. Diem HaMai, Department of Community and Environmental Medicine, University of California, Irvine, Irvine, CA 92697-1825, USA
  • Email:
    diemh@uci.edu
  • CAS Registry Number:
    Manganese (CAS RN 7439-96-5)
  • Federal Fiscal Year:
    2001
  • Performing Organization:
    University of California, School of Public Health, Los Angeles, CA
  • Peer Reviewed:
    True
  • Start Date:
    19990701
  • Source Full Name:
    Free Radical Biology and Medicine
  • End Date:
    20040630
  • Collection(s):
  • Main Document Checksum:
    urn:sha-512:59b2bacc99f4e5d85f6cce6c791136861a789246d87e35489913e13f94db1197d07eb13c1ce2e00dcb4fec82432fff896aa4792fb05829956d06aee7ac8f5d99
  • Download URL:
  • File Type:
    Filetype[PDF - 96.62 KB ]
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