Night Shift Work and Cardiovascular Disease Biomarkers in Female Nurses

Details

• Personal Author:
  Johnson CY ; Lawson, Christina C. ; Rich-Edwards JW ; Schernhammer ES ; Tanz LJ ; Vetter C
• Description:
  Background: Night shift work is associated with cardiovascular disease, but its associations with cardiovascular disease biomarkers are unclear. We investigated these associations in a study of female nurses. Methods: We used data from the Nurses' Health Study II for total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein (HDL) cholesterol, triglycerides, C-reactive protein (CRP), and fibrinogen. The sample sizes for our analysis ranged from 458 (fibrinogen) to 3574 (total cholesterol). From questionnaires, we determined the number of night shifts worked in the 2 weeks before blood collection and total years of rotating night shift work. We used quantile regression to estimate differences in biomarker levels by shift work history, adjusting for potential confounders. Results: Nurses working 1 to 4 recent night shifts had median HDL cholesterol levels 4.4 mg/dL (95% confidence interval [CI]: 0.3, 7.5) lower than nurses without recent night shifts. However, working >/= 5 recent night shifts and years of rotating night shift work were not associated with HDL cholesterol. There was no association between recent night shifts and CRP, but median CRP levels were 0.1 (95% CI: 0.0, 0.2), 0.2 (95% CI: 0.1, 0.4), and 0.2 (95% CI: 0.0, 0.4) mg/L higher among nurses working rotating night shifts for 1 to 5, 6 to 9, and >/=10 years compared with nurses never working rotating night shifts. These associations were attenuated when excluding postmenopausal women and women taking statins. We observed no associations between night shift work and other biomarkers. Conclusions: We found suggestive evidence of adverse short-term and long-term effects of night shift work on select cardiovascular disease biomarkers. [Description provided by NIOSH]
• Subjects:
  Biomarkers Cardiovascular Diseases Cardiovascular System Health Personnel Lipids Occupational Health Safety Surveys And Questionnaires Women
• Keywords:
  Author Keywords: Biomarkers C-reactive Protein Cardiovascular Disease Cardiovascular System Disease Cardiovascular System Disorders Health Surveys Night Shift Work Nurses Nursing Proteins Questionnaires Serum Cholesterol Shift Workers Work Schedules

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• ISSN:
  0271-3586
• Document Type:
  Text
• Funding:
  Grant ; Contract
• Genre:
  Journal Article
• Place as Subject:
  Colorado ; Massachusetts ; Ohio ; OSHA Region 1 ; OSHA Region 5 ; OSHA Region 8
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DFSE - Division of Field Studies and Engineering
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  240-248
• Volume:
  63
• Issue:
  3
• NIOSHTIC Number:
  nn:20058061
• Citation:
  Am J Ind Med 2020 Mar; 63(3):240-248
• Contact Point Address:
  Candice Y. Johnson, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 1090 Tusculum Ave, Mailstop R-15, Cincinnati, OH 45226
• Email:
  cyjohnson@cdc.gov
• Federal Fiscal Year:
  2020
• Performing Organization:
  Brigham and Women's Hospital, Inc., Boston, Massachusetts
• Peer Reviewed:
  True
• Start Date:
  20100801
• Source Full Name:
  American Journal of Industrial Medicine
• End Date:
  20190831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:bde375c68f048d80c91555c44a4616d2ea46c12c7cc19511289b6a7b84c6bb0e5c7a7b6e63a3f0efb058151eb08526a88b1e8f5820bd1adf03767e86f1b0853e
• Download URL:
  https://stacks.cdc.gov/view/cdc/221241/cdc_221241_DS1.pdf
• File Type:
  [PDF - 868.98 KB ]