Interferon-gamma release assays (IGRAs) - blood tests for TB infection

Back to Previous Page

- Add this to...
- Twitter
- Facebook
- Google Bookmarks
- LinkedIn

Interferon-gamma release assays (IGRAs) - blood tests for TB infection

Published Date:

November, 2011

Language:

English

[PDF-179.62 KB]

Details:

Corporate Authors:

National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention (U.S.). Division of Tuberculosis Elimination.

Keywords:

[+]

Description:

What are they? -- How do they work? -- What are the advantages of IGRAs? -- What are the disadvantages and limitations of IGRAs? -- What are the steps in administering an IGRA test? -- How do you interpret IGRA test results? -- Recommendations on when to use IGRA tests -- Can IGRAs be given to persons receiving vaccinations? -- Additional information.

Interferon-Gamma Release Assays (IGRAs) are whole-blood tests that can aid in diagnosing Mycobacterium tuberculosis infection. They do not help differentiate latent tuberculosis infection (LTBI) from tuberculosis disease. Two IGRAs that have been approved by the U.S. Food and Drug Administration (FDA) are commercially available in the U.S: QuantiFERON®-TB Gold In-Tube test (QFT-GIT); T-SPOT®.TB test (T-Spot).

Document Type:

Pamphlet (or booklet)

Collection(s):

Stephen B. Thacker CDC Library collection

Main Document Checksum:

[+]

Supporting Files:

No Additional Files

No Related Documents.

You May Also Like:

Updated guidelines for using interferon gamma release assays to detect Mycobacterium tuberculosis infection -- United States, 2010

Personal Author:

Castro, Kenneth G.; Goldberg, Stefan; Jereb, John A.; LoBue, Philip; Mazurek, Gerald H.; Vernon, Andrew;

Corporate Author:

National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention (U.S.), Division of Tuberculosis Elimination.. Centers for Disease Control and Prevention (U.S.). HIV Medicine Association. Infectious Diseases Society of America. National Institutes of Health (U.S.).

Published:

June 25, 2010

Series:

MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports ; v. 59, no. RR-5

Description:

"This report updates and combines earlier versions of guidelines for the prevention and treatment of opportunistic infections (OIs) in HIV-infected adults (i.e., persons aged [more than or equal to] 18 years) and adolescents (i.e., persons aged ...

Status:

current

File Type:

[PDF - 501.08 KB]
Clinical Application of Interferon-γ Release Assays for the Prevention of Tuberculosis in Countries with Low Incidence

Personal Author:

Lange, Christoph; Mandalakas, Anna M.; Kalsdorf, Barbara; Denkinger, Claudia M.; Sester, Martina;

Published:

Jan 04 2016

Source:

Pathog Immun. 1(2):308-329

Description:

Despite global efforts to control tuberculosis (TB) the estimated number of people who developed TB worldwide increased to an all-time record of more than 10 million in 2015. The goal of the World Health Organization (WHO) to reduce the global incide...

File Type:

[PDF - 368.19 KB]
Unusual Interferon Gamma Measurements with QuantiFERON-TB Gold and QuantiFERON-TB Gold In-Tube Tests

Personal Author:

Powell, Richard D.; Whitworth, William C.; Bernardo, John; Moonan, Patrick K.; Mazurek, Gerald H.;

Published:

Jun 08 2011

Source:

PLoS One. 2011; 6(6).

Description:

Introduction : Interferon gamma (IFN-γ) release assays, such as QuantiFERON®-TB Gold test (QFT-G) and QuantiFERON®-TB Gold In-Tube test (QFT-GIT) are designed to detect M. tuberculosis (Mtb) infection. Recognition of unusual IFN-γ measurements ma...

File Type:

[PDF - 252.88 KB]
Is It Time to Replace the Tuberculin Skin Test With a Blood Test?

Personal Author:

LoBue, Philip A.; Castro, Kenneth G.;

Published:

Jul 18 2012

Source:

JAMA. 308(3):241-242.

File Type:

[PDF - 81.07 KB]
Characteristics Associated with Negative Interferon-γ Release Assay Results in Culture-Confirmed Tuberculosis Patients, Texas, USA, 2013–2015

Personal Author:

Nguyen, Duc T.; Teeter, Larry D.; Graves, Julie; Graviss, Edward A.;

Published:

Mar 2018

Source:

Emerg Infect Dis. 24(3):534-540.

Description:

Interferon-γ release assays (IGRAs) are the preferred diagnostic test for tuberculosis (TB) infection in at-risk populations in developed countries. However, IGRAs have high false-negative rates in patients with TB disease. Population-based studies ...

File Type:

[PDF - 2.00 MB]