RDoC Domains Underlying Emotional Health and Trajectories of Psychopathology in Families of WTC First Responders and Evacuees: A Genome-Wide GxE Study

Details

• Personal Author:
  Geronazo-Alman FL ; Hoven CW
• Description:
  The role of familial/parental factors in modulating youths' reactions to terrorism is supported by the scientific literature, including our findings from youth assessed six months after the World Trade Center (WTC) attacks of 9/11 (N = 8,236). Those findings led to a NICHD-funded grant (Wave 1-2 WTC Family Study) to understand the impact, over time, of parental direct WTC-exposure on their children's psychopathology. For that study, N = 855 families (parents + one child) of WTC First Responders, WTC Evacuees and local Residents were recruited from the WTC Health Registry (WTCHR), as well as 9/11 unexposed Control families. Since initiation of the Wave 1-2 WTC Family Study, NIMH developed the Research Domain Criteria (RDoC) project, a new way to classify mental disorders based on validated behavioral functions. RDoC domains have quickly illuminated the conceptualization of psychopathology by providing a more comprehensive framework of functions/deficits across a spectrum of disorders and the health-illness dimension. Additionally, the explosion of high-throughput technologies has led to a more comprehensive view of the genetic architecture of observable behaviors and of gene-environment interactions (G×E), which may be critical in the development of individualized treatment plans for 9/11 exposed individuals. To date, there has been no other 9/11 investigation that encompasses families of First Responder, WTC and Residential Evacuee families, the most adversely impacted WTC population. Based on findings from the Wave 1-2 WTC Family Study, as well as other epidemiological, behavioral and genetic findings by GPEG regarding these individuals, we assessed these same families for a 3rd wave, to examine how four key RDoC domains of functioning (negative valence; positive valence; cognitive systems; social cognition) are associated upward with (i) long-term psychiatric outcomes (DSM disorders), (ii) emotional health (psychological resilience), and (iii) trajectories of psychopathology, and downward, with interactions between genetic variation and direct/indirect WTC exposures. [Description provided by NIOSH]
• Subjects:
  Behavior Emergency Responders Family Mental Health Nervous System Occupational Health Safety September 11 Terrorist Attacks
• Keywords:
  Children Emergency Responders Families Genetic Factors Mental Health Psychological Effects Rescue Workers Surveillance World Trade Center WTC
• Series:
  Grant Final Reports
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Final Cooperative Agreement Report
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  OEP - Office of Extramural Programs
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-44
• NIOSHTIC Number:
  nn:20067108
• Citation:
  Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, U01-OH-011327, 2022 Dec; :1-44
• Contact Point Address:
  Christina W. Hoven, DrPH, MPH, New York State Psychiatric Institute, 1051 Riverside Drive, New York, NY 10032-1007
• Email:
  Christina.Hoven@nyspi.columbia.edu
• Federal Fiscal Year:
  2023
• Performing Organization:
  New York State Psychiatric Institute
• Peer Reviewed:
  False
• Start Date:
  20160901
• Source Full Name:
  National Institute for Occupational Safety and Health
• End Date:
  20210831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:5f702ed8e95a86b617068d47bda0ddab0e243dec0005742df5b9609e6ae0c1cf3689dd474a1024194e447579bb9ad053fd0bb4d9a1bc4de8f2661f703b6aad7a
• Download URL:
  https://stacks.cdc.gov/view/cdc/219185/cdc_219185_DS1.pdf
• File Type:
  [PDF - 1.42 MB ]