Impact of WTC Dust on Immune Functions and Prostate Cancer Promotion

Details

• Personal Author:
  Aaronson SA ; Mulholland D
• Description:
  Epidemiological evidence indicates an increased incidence of prostate cancer and some other tumors in WTC responders. We showed that in mouse genetic models with initiating oncogenic lesions in prostate, WTC dust exposure induced acute pulmonary inflammation with persistence of inflammatory cytokines in lung, peripheral blood and in prostate. WTC dust exposure did not detectably increase prostate tumor incidence in wild type mice but did promote in vivo growth of initiated prostate epithelial cells and transplanted tumor cells. These findings are consistent with growth promotion by an inflammatory/immune mechanism. When age/race/tumor grade matched prostate tumor sections from WTC responders versus unexposed individuals were analyzed by mass spec multiplex imaging, global DNA methylation and gene expression analysis, we observed that immune/inflammatory biomarkers were enriched in WTC prostate cancers. Further studies are needed to confirm and extend these findings and to test whether the levels of dust exposure at the WTC sites correlate with the biomarkers identified. These studies have resulted in dissemination of results to the scientific community and the public at large through 3 publications to date. [Description provided by NIOSH]
• Subjects:
  Biomarkers Dust Emergency Responders Immune System Neoplasms Occupational Health Safety September 11 Terrorist Attacks
• Keywords:
  Cancer Rates Dust Exposure Emergency Responders Immune Reaction Prostate Cancer Rescue Workers Surveillance World Trade Center WTC
• Series:
  Grant Final Reports
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Final Cooperative Agreement Report
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  OEP - Office of Extramural Programs
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-13
• NIOSHTIC Number:
  nn:20066992
• Citation:
  Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, U01-OH-011328, 2022 Dec; :1-13
• Contact Point Address:
  Stuart A. Aaronson, MD, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029-6574
• Email:
  stuart.aaronson@mssm.edu
• Federal Fiscal Year:
  2023
• Performing Organization:
  Icahn School of Medicine at Mount Sinai, New York
• Peer Reviewed:
  False
• Start Date:
  20160901
• Source Full Name:
  National Institute for Occupational Safety and Health
• End Date:
  20210831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:f34571479c2141bb46b3ecd23dd4672cf496b3afcff408cf517ced773814200b628349e8bba2a0af767d7c06eb6956b79aed9a83d05c55f14d456b6e8465e072
• Download URL:
  https://stacks.cdc.gov/view/cdc/219179/cdc_219179_DS1.pdf
• File Type:
  [PDF - 1.09 MB ]