National Mesothelioma Virtual Bank, Continued Innovation

Details

• Personal Author:
  Becich MJ ; Ganapathiraju MK ; Hartman DJ ; Pennathur A ; Silverstein JC
• Description:
  The National Mesothelioma Virtual Bank (NMVB) is a translational research resource for a rare asbestos related cancer which affects the lining cells (mesothelium) of the pleural (lung) and peritoneal (abdomen) cavities of the affected patients. The NMVB collects biospecimens, clinical/outcomes data derived from electronic medical records and asbestos occupational/exposure questionnaires from patients with mesothelioma and shares them with cancer researchers to develop biomarkers which help prevent and treat this nearly uniformly fatal cancer. In the last funding period (2016-21), NMVB added 472 cases to the nearly 1700 cases is shared with the research community to help develop insights toward halting the progression and death from this deadly cancer. In addition, NMVB supplied biospecimens and data to 26 research teams nationally and internationally despite the downturn in research in 2020 and 2021 during COVID. The NMVB supported 28 publications during this funding period resulting in a record number of citations in both 2020 and 2021 and an h-index of 15 and an i10-index of 41 which is remarkable for a rare disease. NMVB contributed to The Cancer Genome Atlas program 63 cases of pleural (lung) mesothelioma which expanded the impact of this CDC NIOSH funded resource resulting in a Cancer Discovery publication in 2018 that has been cited 257 times (as of 11/29/21). The discovery of the BAP1 gene related to mesothelioma was also a major discovery facilitated by this resource with contributions from both the research community and key personnel of NMVB. Finally, to expand the impact of NMVB, we have added protein-protein interaction data from public data sources to NMVB as part of the quest for continued innovation for the novel biospecimen and clinical/outcomes data resource. [Description provided by NIOSH]
• Subjects:
  Biomarkers Database Diagnosis Laboratories Neoplasms Occupational Health Pathology Safety Software
• Keywords:
  Biological Materials Cancer Clinical Diagnosis Computer Software Databases Information Systems Laboratory Testing Mesothelioma
• Series:
  Grant Final Reports
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Final Cooperative Agreement Report
• Place as Subject:
  OSHA Region 3 ; Pennsylvania
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  OEP - Office of Extramural Programs
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-8
• NIOSHTIC Number:
  nn:20066169
• Citation:
  Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, U24-OH-009077, 2021 Nov; :1-8
• Email:
  becich@pitt.edu
• Federal Fiscal Year:
  2022
• NORA Priority Area:
  Construction ; Manufacturing
• Performing Organization:
  University of Pittsburgh at Pittsburgh
• Peer Reviewed:
  False
• Start Date:
  20060901
• Source Full Name:
  National Institute for Occupational Safety and Health
• End Date:
  20260831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:9829624b34587ae22d1ffb69bb77b92e973aba3026cc633bc9e8cb92036691eee2547d3761c502dc52f0969215eb040217bb26563cb56f4e9434321c1ed073d3
• Download URL:
  https://stacks.cdc.gov/view/cdc/219144/cdc_219144_DS1.pdf
• File Type:
  [PDF - 273.12 KB ]