Longitudinal Genome-Wide Transcriptome Study of PTSD Symptom Change in WTC Responders

Details

• Personal Author:
  Bromet E ; Kuan PF ; Luft B ; Waszczuk M
• Description:
  The 9/11 World Trade Center terrorist attack was a massive disaster, resulting in longterm physical and psychological trauma to the responders, in particular PTSD and lower respiratory symptoms (LRS), with 10-20% of responders experiencing symptoms consistent with the diagnosis of PTSD a decade later. Our group found that PTSD in WTC responders is closely linked to their respiratory diseases, and PTSD mediated the relationship between WTC exposures and LRS. Genetic vulnerability and gene-environment interactions have been implicated in the etiology of PTSD. In this study, we aim to evaluate association between changes in gene expression (gene, isoform and alternative splicing (AS)) with changes in PTSD symptom severity, and PTSD symptom dimension (re-experiencing, avoidance, numbing, hyperarousal). We also aim to identify the genetic pathways implicated by these changes; and identify the Gene Expression Signature (GES) associated with change in PTSD symptoms. An in-depth understanding of the biological processes underpinning PTSD, and identification of its GES carries clinical significance by identifying processes that maintain PTSD and can be targeted for intervention, and will inform treatment development for WTC responders as well as other trauma-exposed populations. Our results indicated that avoidance differed the most from other dimensions with respect to DE genes and AS events. Gene set enrichment analysis (GSEA) identified pathways involved in inflammatory and metabolic processes, which may have implications in the treatment of PTSD. Overall, the findings shed a novel light on the wide range of transcriptomic alterations associated with PTSD at the gene and AS levels. The results of DE analysis associated with PTSD dimensions highlights the importance of studying PTSD symptom heterogeneity. [Description provided by NIOSH]
• Subjects:
  Emergency Responders Energy Metabolism Genetics Lung Diseases Mental Health Occupational Health Respiratory Tract Diseases Safety September 11 Terrorist Attacks
• Keywords:
  Disaster Sites Emergency Responders Etiology First Responders Metabolism Post-traumatic Stress Disorder Psychological Stress Psychology PTSD Pulmonary System Disorders Respiratory System Disorders Traumatic Injuries World Trade Center WTC

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• Series:
  Grant Final Reports
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Final Cooperative Agreement Report
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  OEP - Office of Extramural Programs
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-35
• NIOSHTIC Number:
  nn:20066115
• Citation:
  Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, U01-OH-011478, 2021 Aug; :1-35
• Contact Point Address:
  Peifen Kuan, State University New York Stony Brook, Stony Brook, NY 11794-3362
• Email:
  peifen.kuan@stonybrook.edu
• Federal Fiscal Year:
  2021
• Performing Organization:
  State University of New York at Stony Brook
• Peer Reviewed:
  False
• Start Date:
  20170701
• Source Full Name:
  National Institute for Occupational Safety and Health
• End Date:
  20200630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:fcec614f64c6f42e78ed482178be2d543b50eb8de24eb93ab1a28b9c779c51df3b96a87c256ba9571663c283eec24e9cb4b8280e281dbefdd15ea50c5248dd25
• Download URL:
  https://stacks.cdc.gov/view/cdc/219140/cdc_219140_DS1.pdf
• File Type:
  [PDF - 1.90 MB ]