Cooperative Research Agreements Related to the World Trade Center Health Program

Details

• Personal Author:
  Verma AK
• Description:
  We continue to prospectively follow the entire FDNY cohort of firefighters for cancer incidence and have built a biorepository of samples consisting of fractionated blood components and serum from 2000+ WTC-exposed firefighters and non-WTC-exposed firefighter controls. Using this cohort, we have conducted preliminary studies in 781 WTC-exposed firefighters that demonstrate a significantly higher prevalence of monoclonal gammopathy of undetermined significance (MGUS), a precursor for multiple myeloma. Furthermore, we have conducted deep targeted genome sequencing of a pilot cohort of WTC-exposed firefighters (N=481) and non-WTC-exposed age matched firefighter controls (N=52). We observed a high incidence of Clonal hematopoiesis (CH) and leukemia associated mutations (48/481; 10%) in WTC-exposed firefighters. The rate of mutations in controls was significantly less and is comparable to age matched controls in published studies . Clonal hematopoiesis (CH) is acquisition of leukemia associated somatic mutations that carry increase risk of hematologic cancer as well as all-cause mortality. The mutations seen in WTC-exposed firefighters affected DNMT3A, TET2, TP53, Splicing and other commonly recurrently mutated genes. These mutations suggest a high rate of CH, and CH in other cohorts has been shown to be associated with risk for development of myeloid neoplasms, inflammatory conditions and heart diseases. [Description provided by NIOSH]
• Subjects:
  Aging Cardiovascular Diseases Cardiovascular System Firefighters Genetics Men Neoplasms Occupational Health Risk Assessment Risk Factors Safety September 11 Terrorist Attacks

  More +
• Keywords:
  Age Groups Cancer Fire Fighters Genes Genomics Heart Disease Hematopoiesis Humans Mutation Physiological Effects Prostate Cancer Risk Factors Sampling Screening Programs Sociological Factors World Trade Center WTC

  More +
• Series:
  Grant Final Reports
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Final Cooperative Agreement Report
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  OEP - Office of Extramural Programs
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-11
• NIOSHTIC Number:
  nn:20065894
• Citation:
  Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, U01-OH-011933, 2021 Nov; :1-11
• Contact Point Address:
  Amit K Verma, MD, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461-1900
• Email:
  amit.verma@einsteinmed.org
• Federal Fiscal Year:
  2022
• Performing Organization:
  Albert Einstein College of Medicine, Bronx, New York
• Peer Reviewed:
  False
• Start Date:
  20190101
• Source Full Name:
  National Institute for Occupational Safety and Health
• End Date:
  20200630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:f195323508109f9f9341a68255f183447fe396249457f6bdbd35451f7c1b88f5bebbff3d725fce8f3813ff109052c08669ce3771d1d29b80cc4159870fdb0284
• Download URL:
  https://stacks.cdc.gov/view/cdc/219130/cdc_219130_DS1.pdf
• File Type:
  [PDF - 1.10 MB ]