Deciphering Occupational Asthma Pathogenesis Caused by Isocyanate

Details

• Personal Author:
  Wisnewski A
• Description:
  The studies focused on important industrial chemicals necessary to make polyurethane, which is important to our economy and our culture and safety. An important chemical needed to make polyurethane is diisocyanate, which is known to cause asthma. Currently workers must use protective equipment to work with the chemical and there are no tests widely available to establish chemical sensitivity (asthma). The data from the project to date identify important characteristics of asthma caused by diisocyanate in a mouse model that parallels human disease. The data identify new potential avenues for treatment and prevention and describe differences vs. "environmental asthma" that may make the disease intractable to treatment with new anti-inflammatory biologics. The data also identify important aspects of biochemical reactivity of diisocyanate with self-molecules and identify biomarkers of exposure that will likely be applicable to human exposure surveillance and disease prevention in the future, to help enable safety of workers exposed to diisocyanate on the job. Important outcomes of the award are: 1) Multiple medical journal manuscripts describing underlying biochemistry of exposure, reactivity with self. 2) New insight into basic mechanisms of disease (importance of chloride channels, and "innate" immune system). 3) Identification of exposure biomarker for surveillance of workplace exposure. 4) Chemical Methods for synthesizing standard for biomonitoring chemical exposure at work. [Description provided by NIOSH]
• Subjects:
  Animals Asthma, Occupational Biochemistry Biomarkers Environmental Exposure Hazardous Substances Immune System Isocyanates Occupational Exposure Occupational Health Safety

  More +
• Keywords:
  Animal Studies Biochemical Effects Chemical Hazards Cytokines Diisocyanates Environmental Exposure Immune Reaction Industrial Exposures Occupational Asthma
• Series:
  Grant Final Reports
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Final Grant Report
• Place as Subject:
  Connecticut ; OSHA Region 1
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  OEP - Office of Extramural Programs
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-13
• NIOSHTIC Number:
  nn:20065690
• Citation:
  Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, R01-OH-010941, 2021 Nov; :1-13
• Email:
  adam.wisnewski@yale.edu
• Federal Fiscal Year:
  2022
• NORA Priority Area:
  Manufacturing ; Construction
• Performing Organization:
  Yale University, New Haven, Connecticut
• Peer Reviewed:
  False
• Start Date:
  20160801
• Source Full Name:
  National Institute for Occupational Safety and Health
• End Date:
  20200731
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:bc01319f46801acdb6cb006cdc56c6a4ea40c104ab71dc7a24224f1df21e09a36d08845aebca8d209f5bda36a749fc0c24a9971c906ba027b65f4de1246a9910
• Download URL:
  https://stacks.cdc.gov/view/cdc/219117/cdc_219117_DS1.pdf
• File Type:
  [PDF - 246.22 KB ]