Details:

Alternative Title:
Environ Health Perspect
Publisher's site:
http://dx.doi.org/10.1289/ehp.1206093
Personal Author:
Ye, Xiaoyun; Zhou, Xiaoliu; Hennings, Ryan; Kramer, Joshua; Calafat, Antonia M.;
Ye, Xiaoyun; Zhou, Xiaoliu; Hennings, Ryan; Kramer, Joshua; Calafat, Antonia M.; Less -
Description:
Biomonitoring studies are conducted to assess internal dose (i.e., body burden) to environmental chemicals. However, because of the ubiquitous presence in the environment of some of these chemicals, such as bisphenol A (BPA), external contamination during handling and analysis of the biospecimens collected for biomonitoring evaluations could compromise the reported concentrations of such chemicals.|We examined the contamination with the target analytes during analysis of biological specimens in biomonitoring laboratories equipped with state-of-the-art analytical instrumentation.|We present several case studies using the quantitative determination of BPA and other organic chemicals (i.e., benzophenone-3, triclosan, parabens) in human urine, milk, and serum to identify potential contamination sources when the biomarkers measured are ubiquitous environmental contaminants.|Contamination with target analytes during biomonitoring analysis could result from solvents and reagents, the experimental apparatus used, the laboratory environment, and/or even the analyst. For biomonotoring data to be valid-even when obtained from high-quality analytical methods and good laboratory practices-the following practices must be followed to identify and track unintended contamination with the target analytes during analysis of the biological specimens: strict quality control measures including use of laboratory blanks; replicate analyses; engineering controls (e.g., clean rooms, biosafety cabinets) as needed; and homogeneous matrix-based quality control materials within the expected concentration ranges of the study samples.
Subject:
[+]
Benzhydryl Compounds
Benzophenone-3
Biomonitoring
Bisphenol A
Chromatography, High Pressure Liquid
Commentary
Environmental Monitoring
Environmental Pollutants
Exposure Assessment
Parabens
Phenols
Reagent Blank
Tandem Mass Spectrometry
Triclosan

Source:
Environ Health Perspect. 2013; 121(3):283-286.;
Document Type:
Journal Article;
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:e6c0f092c4864543989858ce71e23900b7cc81dd6d2d362ab25bcb1c388a9a75
File Type:

Supporting Files

• 	license.txt	txt
  	ehp.1206093.g001.gif	gif
  	ehp.1206093.g001.jpg	jpeg
  	ehp.1206093.g002.gif	gif
  	ehp.1206093.g002.jpg	jpeg
  	ehp.1206093.g003.gif	gif
  	ehp.1206093.g003.jpg	jpeg
  	ehp.1206093.nxml	txt

More +