Target Organ DNA Damage in Coke Oven Workers

Details

• Personal Author:
  Talaska G
• Description:
  Making accurate exposure measurements for polycyclic aromatic hydrocarbons (PAH) is a difficult problems facing the occupational health professional. PAH have low acute toxicity, but many are recognized carcinogens. They have a low vapor pressure, but can be adsorbed onto inhaled particulates and are also readily absorbed through the skin. When the materials are heated, they produce dusts, vapors or fumes; and while respirators are used to limit uptake, it is difficult to estimate their efficiency in practice. The impact of differences in body fat and activity (respiration rate) are simply unknown. For these reasons, biological monitoring is being used increasingly to estimate exposure. The credo of industrial hygiene is "to protect the health of the worker." One of the major advances to this end has been the development of exposure values for professional practice, e.g., the TLVs and BEIs. A BEI has been established for PAH exposure using the internal dose marker 1hydroxypyrene (1HP) as the index. However, due to data limitations, this BEI is not related to health effects directly or indirectly (as a TLV - equivalent). Instead, the BEI was set as an advisory level using the distribution levels in the general population including the levels seen in tobacco smokers. The epidemiology of tobacco smokers clearly indicates excess lung and urinary bladder cancer risks in this population at 1HP levels that are lower than those seen in many occupational groups. While it is acknowledged that tobacco smoke contains many materials other than PAH which may add to its carcinogenicity, basically, this means that it is not known whether the BEI protects workers from the most significant health effects of PAH exposure, genotoxicity and cancer. The specific aims of this study were to: 1. Determine the relationship between urinary levels of 1-hydroxypyrene (1HP) and levels of carcinogen-DNA adducts in exfoliated urothelial cells (urine sample sediments). Determine if a dose response exists and the degree of association. These data will allow us to determine at what point 1HP levels are related to significant increases in PAH DNA adduct levels in the target organ, the urinary bladder. If such a level exists, it will be important in setting health exposure guidelines for PAH that are based on human health effects instead of background population levels, as they now are. There is some indication that the current BEI for PAH may not prevent the occurrence of genetic damage. This study will help to determine if that is the case and supply important data needed to revise the BEI if so indicated. These internal dose levels will be compared to air PAH levels, data which has been collected by our collaborators in Germany. 2. Determine the levels of 1HP and 1HP glucuronide using HPLC techniques and our recently developed sensor probe which could potentially be used to measure each of these biomarkers in real time. [Description provided by NIOSH]
• Subjects:
  Air Pollutants, Occupational Biomarkers Carcinogens Hydrocarbons Manufacturing And Industrial Facilities Occupational Exposure Occupational Health Polycyclic Aromatic Hydrocarbons Safety Solvents
• Keywords:
  Biological Monitoring Bladder Disease Dose Response Exposure Assessment Fumes Manufacturing Occupational Exposure Polycyclic Aromatic Hydrocarbons Vapors
• Series:
  Grant Final Reports
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Final Grant Report
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  OEP - Office of Extramural Programs
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-10
• NIOSHTIC Number:
  nn:20058768
• NTIS Accession Number:
  PB2022-100290
• Citation:
  Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, R01-OH-009652, 2013 Apr; :1-10
• Contact Point Address:
  Glenn Talaska, Ph.D., CIH, Professor, Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, OH 45267-0056
• Email:
  glenn.talaska@uc.edu
• CAS Registry Number:
  1-Hydroxypyrene (CAS RN 5315-79-7)
• Federal Fiscal Year:
  2013
• NORA Priority Area:
  Manufacturing
• Performing Organization:
  University of Cincinnati
• Peer Reviewed:
  False
• Start Date:
  20090901
• Source Full Name:
  National Institute for Occupational Safety and Health
• End Date:
  20120831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:8ae114b95557acdb11cb2e28ae52b28204a2c15705e7ebbc350b1b347645a3d70caee1b5c0c31872f73db14ae5d3ded361673389af417ea2ce77074dccb4c492
• Download URL:
  https://stacks.cdc.gov/view/cdc/218955/cdc_218955_DS1.pdf
• File Type:
  [PDF - 852.62 KB ]