Methods to Assess Personal Exposures to Airborne Metallic Nanoparticles

Details

• Personal Author:
  Kostle P ; Peters TM
• Description:
  When inhaled, nanoparticles can elicit adverse cardiopulmonary health outcomes and their toxicity, particularly for metals and metal oxides, can be substantially greater than that of larger particles of the same composition. No standard measurement methods are available to quantitatively assess personal exposures to engineered nanoparticles, and without such methods, the extent to which workers are at risk from inhalation of nanoparticles is unknown. The laboratory work carried out in this research standardized and validated measurement methods needed to quantify personal exposure to a range of metallic nanoparticles that are commonly incorporated into commercial products. We developed an innovative nanoparticle respiratory deposition (NRD) sampler to collect nanoparticles specifically (separate from the larger particles in workplace air) and in a manner that reflects their deposition in the respiratory tract (Aim 1). We also developed and validated methods to analyze the content of metal in the nanoparticles collected with the NRD sampler and common respirable samplers (Aim 2). These sampling and analysis methods are easily adaptable by industrial hygiene practitioners to provide the system needed to assess worker exposure to metal nanoparticles. They represent enabling tools to study potential epidemiological relationships among metallic nanoparticle exposures and adverse acute health effects. [Description provided by NIOSH]
• Subjects:
  Manufacturing And Industrial Facilities Metals Occupational Exposure Occupational Health Respiratory System Safety
• Keywords:
  Cardiopulmonary Function Industrial Hygiene Inhalation Manufacturing Metal Oxides Nanoparticles Occupational Exposure Respiratory Function
• Series:
  Grant Final Reports
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Final Grant Report
• Place as Subject:
  Iowa ; OSHA Region 7
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  OEP - Office of Extramural Programs
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-19
• NIOSHTIC Number:
  nn:20056808
• NTIS Accession Number:
  PB2019-101416
• Citation:
  Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, R21-OH-009920, 2013 Nov; :1-19
• Contact Point Address:
  Thomas M. Peters, PhD, CIH, The University of Iowa, S331 CPHB; 105 River St., Iowa City, Iowa 52245
• Email:
  thomas-m-peters@uiowa.edu
• Federal Fiscal Year:
  2014
• NORA Priority Area:
  Manufacturing
• Performing Organization:
  University of Iowa
• Peer Reviewed:
  False
• Start Date:
  20100901
• Source Full Name:
  National Institute for Occupational Safety and Health
• End Date:
  20130831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:e807e8e61de9e33ab444a9f95ce1846497e852699eb4e4dc243c7c20708a9863bf13629c1d2b85e0f86fd9c90a66264a92909181325110b7a4a13f3a6e22d361
• Download URL:
  https://stacks.cdc.gov/view/cdc/218913/cdc_218913_DS1.pdf
• File Type:
  [PDF - 637.52 KB ]