Exposure to Bisphenol A & Reproductive Effect in Humans

Details

• Personal Author:
  Checkoway, Harvey ; Gao E ; Herrinton L ; Li D-K ; Seixas, Noah S. ; Wang J ; Xue S ; Yuan W ; Zhou Z
• Description:
  To examine the health effects of exposure to bisphenol-A (BPA) in the human population, we conducted an occupational cohort study in several regions in China where occupational exposure to BPA existed. The exposed group consisted of workers who were exposed to BPA in the workplace. The unexposed cohort consisted of workers similar to the exposed workers in the same locations, but without exposure to BPA in the workplace. A total of 1,937 subjects including workers, their spouses and their children, if any, participated in the study. BPA exposure was measured both through workplace monitoring (for the exposed workers) and biomarker assays (urine and blood specimens). We examined the impact of BPA exposures on the male reproductive system (semen quality and sexual dysfunction), female pregnancy outcomes (shortened anogenital distance and decreased birth weight), and hormone profiles. After controlling for other confounding factors, we observed the following findings: 1. High urine BPA level in male participants is associated with lower sperm quality. 2. Exposure to high BPA level increases the risk of male sexual dysfunction. 3. Female exposure to high BPA during pregnancy is associated with a shortened anogenital distance (AGD) in male offspring, an indication of increased risk of genital anomaly. 4. Female exposure to high BPA during pregnancy is associated with decreased birth weight among offspring. These findings provide the first piece of epidemiological evidence from human studies demonstrating that high BPA exposure level presents a detrimental effect to human health, especially to the reproductive systems in this case. The observed BPA adverse effect on both male and female reproductive systems is consistent with the findings from animal studies. Our findings have filled the knowledge gap due to a lack of human studies and provide important information for the scientific community and regulatory agencies when evaluating the safety of BPA exposure in the workplace and the general environment. [Description provided by NIOSH]
• Subjects:
  Biomarkers Cohort Studies Occupational Exposure Occupational Health Pregnancy Safety Urogenital System
• Keywords:
  Bisphenol A Cohort Studies Health Effects Humans Occupational Exposure Prenatal Exposure Reproductive Effects
• Series:
  Grant Final Reports
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Final Grant Report
• Place as Subject:
  California ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  OEP - Office of Extramural Programs
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-12
• NIOSHTIC Number:
  nn:20056764
• NTIS Accession Number:
  PB2022-100318
• Citation:
  Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, R01-OH-007580, 2012 Feb; :1-12
• Contact Point Address:
  De-Kun Li, MD, PhD, Kaiser Permanente Division of Research, 2000 Broadway, Oakland, CA 94612-2304
• Email:
  De-Kun.Li@kp.org
• Federal Fiscal Year:
  2012
• NORA Priority Area:
  Disease and Injury: Fertility and Pregnancy Abnormalities
• Performing Organization:
  Kaiser Foundation Research Institute
• Peer Reviewed:
  False
• Start Date:
  20030930
• Source Full Name:
  National Institute for Occupational Safety and Health
• End Date:
  20110929
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:82b84e8986cab5f6b39fbbdbd3281b8b6ac5f0d967c11377bbfc49e64b318f77c294f557893faa9b0a792d04e362f5ed3cb9965ec0faf2cc7d264831fc1b1313
• Download URL:
  https://stacks.cdc.gov/view/cdc/218911/cdc_218911_DS1.pdf
• File Type:
  [PDF - 596.95 KB ]