Mycobacteria in Metalworking Fluids

Details

• Personal Author:
  Yadav JS
• Description:
  Mycobacteria have been implicated in respiratory disorders in workers exposed to metalworking fluids. Therefore detection and quantitation of Mycobacteria in MWF is warranted for early assessment and elimination of these occupational hazards. The proposed study (aim 1) has yielded more efficient and simplified DNA-based tools for mycobacterial contamination monitoring in occupational MWF environments. Biocide susceptibility studies (aim 2) have provided a protocol for rapidly assessing the comparative biocide resistance of prevalent strains of mycobacteria in commercial MWF and provided solution to the need for early identification of biocide resistant mycobacteria in MWF operations. Data on relative resistance of the prevalent strains against the currently used biocides may provide direction on the judicious use of these biocides and better fluid management practices. These studies will also provide the basis for development of more effective biocides (effective against identified resistant MWF strains of mycobacteria) and formulation of a representative test inoculum (containing most resistant and sensitive strains of mycobacteria) for evaluation and testing of new biocides, which may eventually lead to the development of improved MWF and biocide formulations. Immunological characterization of MWF-prevalent NTM strains proposed under Aim 3 has helped identify the potentially immunogenic strains and their antigens that may have relevance to HP and other respiratory immune disorders in exposed workers. The information generated on antigenic potential of MWF-prevalent NTM strains will help in more informed design and interpretation of future epidemiological studies on MWF-linked illnesses. Identification of immunogenic strains and antigens will help develop future immunodiagnostic tests both for exposure assessment and clinical diagnosis of MWF-linked immune disorders such as HP in the exposed machine workers and could thus be critical for developing diagnostic and intervention strategies. [Description provided by NIOSH]
• Subjects:
  Antigens Immune System Lung Diseases Manufacturing And Industrial Facilities Occupational Exposure Occupational Health Respiratory Tract Diseases Safety
• Keywords:
  Immune Reaction Lung Disease Machine Operators Metalworking Fluids MWFs Mycobacterium Occupational Exposure
• Series:
  Grant Final Reports
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Final Grant Report
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  OEP - Office of Extramural Programs
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-9
• NIOSHTIC Number:
  nn:20056249
• NTIS Accession Number:
  PB2019-101125
• Citation:
  Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, R01-OH-007364, 2013 Nov; :1-9
• Federal Fiscal Year:
  2014
• NORA Priority Area:
  Manufacturing
• Performing Organization:
  University of Cincinnati
• Peer Reviewed:
  False
• Start Date:
  20010930
• Source Full Name:
  National Institute for Occupational Safety and Health
• End Date:
  20170731
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:c001e72e5a26d61439f9f492ffb76824b3f3bd8948e0417f1488b033bb1912d6400d6deb4b550dc8d9d3cd2ccf60cafcff63a2373ac29c495a2d14731e0eb70e
• Download URL:
  https://stacks.cdc.gov/view/cdc/218885/cdc_218885_DS1.pdf
• File Type:
  [PDF - 1.90 MB ]