Post-9/11 Incidence of Systematic Autoimmune Diseases in the FDNY Cohort

Details

• Personal Author:
  Webber MP
• Description:
  The overall goal of this two-year project was to calculate the incidence of selected systemic autoimmune diseases (SAID) in 21,786 World Trade Center (WTC)-exposed and unexposed firefighters and emergency medical service (EMS) workers and to estimate the association between intense WTC exposure and SAID. This proposal originated from the World Trade Center Health Program at the Fire Department of New York City (FDNY) where investigators have full access to FDNY monitoring and treatment records, excellent cohort retention rates, demonstrated ability to contact members for additional information, as required, and accurate estimates of person-time at risk from employment records. The following SAID diagnoses were included: systemic lupus erythematosus (SLE), antiphospholipid syndrome (APS), systemic sclerosis (SSc, including diffuse or limited), inflammatory myositis (dermatomyositis, polymyositis, or inclusion-body myositis), Sjogren's syndrome, rheumatoid arthritis (RA), and inflammatory arthritis (i.e., psoriatic arthritis and spondyloarthritis). There had been no epidemiologic studies of SAID incidence or prevalence in WTC-exposed cohorts. WTC-related SAID arose as a concern because previous studies of non-WTC exposed workers demonstrated increased risk of SAID including SLE, SSc and RA, after exposure to agents such as silica, which was known to be present at the WTC disaster site. The specific aims of this proposal were to: Aim 1: Estimate the incidence of confirmed cases of SAID in the FDNY population (firefighters and EMS workers) from 9/11/2001 until 9/10/2013. Aim 2: Perform a nested case-control study to estimate the effect size of WTC exposure on confirmed cases of all subtypes of SAID combined. [Description provided by NIOSH]
• Subjects:
  Emergency Responders Environmental Exposure Firefighters Occupational Health Risk Assessment Risk Factors Safety September 11 Terrorist Attacks Silicon Dioxide
• Keywords:
  Autoimmune Diseases Emergency Medical Services Workers Exposure Levels Fire Fighters Monitoring Systems Recordkeeping Risk Factors Silica Treatment World Trade Center WTC

  More +
• Series:
  Grant Final Reports
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Final Cooperative Agreement Report
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  OEP - Office of Extramural Programs
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-10
• NIOSHTIC Number:
  nn:20048373
• NTIS Accession Number:
  PB2016-104194
• Citation:
  Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, U01-OH-010513, 2016 Jan; :1-10
• Contact Point Address:
  Mayris P. Webber, DrPH, MPH, Montefiore Medical Center & Albert Einstein College of Medicine, Fire Department of the City of New York, 9 Metrotech Center, Brooklyn, NY 11201
• CAS Registry Number:
  Silica (CAS RN 7631-86-9)
• Federal Fiscal Year:
  2016
• Performing Organization:
  Albert Einstein College of Medicine, New York
• Peer Reviewed:
  False
• Start Date:
  20130701
• Source Full Name:
  National Institute for Occupational Safety and Health
• End Date:
  20150630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:af269d0cde793f312283e9d7c1adae783679d409413776ca93df6bc742a2af48554fb8e8cc2baecc222f264eda33732719cc5c28cc85c6b4ce91d01d5230d775
• Download URL:
  https://stacks.cdc.gov/view/cdc/218643/cdc_218643_DS1.pdf
• File Type:
  [PDF - 109.59 KB ]