Beryllium Disease Natural History and Exposure-Response

Details

• Personal Author:
  Newman, Lee S.
• Description:
  BeS progresses to CBD at a rate of 7-11 % per year. Beryllium-sensitized patients merit medical counseling and surveillance for signs of progression to disease. Medical surveillance identifies individuals with CBD of whom 22% progress to treatment with steroids. Parameters that seem to best predict progression specific to CBD are changes in forced vital capacity (FVC) over time and changes in A-a gradient with exercise. More than 50% of the beryllium machining particles in the breathing zone were less than 10 m in aerodynamic diameter. This small particle size may result in beryllium deposition into the deepest portion of the lung and may explain elevated rates of sensitization among beryllium machinists. A high percentage of the particles generated during machining are less than 0.6microm in aerodynamic diameter and from 8% to 10% of the aerosol generated may be deposited in the deep portions of the lung. Measurable beryllium contamination on workers hands and inside their vehicles indicates that take-home beryllium exposure is still a significant risk. Worker risk notification programs can positively affect workers self-protective attitudes and behaviors. [Description provided by NIOSH]
• Subjects:
  Blood Genetics Hematologic Tests Lung Diseases Occupational Health Respiratory System Respiratory Tract Diseases Safety Workplace
• Keywords:
  Biological-effects Blood-analysis Bronchial-cancer Genetic-factors Lung-disease Lymphocytes Occupational-respiratory-disease Respiratory-system-disorders Work-environment
• Series:
  Grant Final Reports
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Final Cooperative Agreement Report
• Place as Subject:
  Colorado ; OSHA Region 8
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  OEP - Office of Extramural Programs
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-17
• NIOSHTIC Number:
  nn:20022216
• NTIS Accession Number:
  PB2004-104522
• Citation:
  Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, U60-CCU-812221, 2002 Jan; :1-17
• Contact Point Address:
  National Jewish Medical and Research Center, Division of Environmental and Occupational Health Sciences, 1400 Jackson street, Denver, CO 80206
• CAS Registry Number:
  Beryllium (CAS RN 7440-41-7)
• Federal Fiscal Year:
  2002
• Performing Organization:
  National Jewish Medical and Research Center, Division of Environmental and Occupational Health Sciences, Denver, Colorado
• Peer Reviewed:
  False
• Start Date:
  19950930
• Source Full Name:
  National Institute for Occupational Safety and Health
• End Date:
  20000929
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:c0868c70b795050e067ac6da53b2f1f37347739c11d5eed941f76c1f876249597082253db1781e4e183348743ea67c6f1dcfe9c28781dc4dbe378f92c3944e7d
• Download URL:
  https://stacks.cdc.gov/view/cdc/217986/cdc_217986_DS1.pdf
• File Type:
  [PDF - 408.95 KB ]