Susceptibility to Genetic Damage from Butadiene

Details

• Personal Author:
  Kelsey KT
• Description:
  Exposure to butadiene has been assessed with 8-hour time weighted average personal sampling as well as urine collection and metabolite determination. Significant data have been collected by questionnaire and blood has also been collected. Early analysis of the data reveals baseline cytogenetic changes in the exposed group to be unrelated to time-weighted average measurements of exposure. Urine was collected and there is no relationship between induced cytogenetic damage and urinary measures of exposure to butadiene. However, examination of high SCE frequency cells reveals that there is some relationship between length in the trade and high frequency SCE cells present in workers. Also, one individual who had previously been noted to have a very high hprt mutant fraction was also sensitive to diepoxybutane in vitro. Thus our work indicates that acute exposure to 1,3-butadiene was not associated with induction of chromosomal abnormalities. However, tenure in the trade was associated with production of high SCE frequency cells. [Description provided by NIOSH]
• Subjects:
  Butadienes Carcinogens Neoplasms Occupational Health Safety
• Keywords:
  Cancer Gene-mutation Humans
• Series:
  Grant Final Reports
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Final Grant Report
• Place as Subject:
  Massachusetts ; OSHA Region 1
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  OEP - Office of Extramural Programs
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-5
• NIOSHTIC Number:
  nn:20000992
• Citation:
  Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, K01-OH-000110, 1995 Jan; :1-5
• CAS Registry Number:
  1,3-Butadiene (CAS RN 106-99-0)
• Federal Fiscal Year:
  1995
• Performing Organization:
  Harvard University
• Peer Reviewed:
  False
• Start Date:
  19910930
• Source Full Name:
  National Institute for Occupational Safety and Health
• End Date:
  19940929
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:e02a8ecf257d3dae17eaab3960a576becc33b1b32e82be4f522d4f3cd5c714d6166f437a8ce4191fbdce959e5185a9618f3c0e4417e61ad48e880927ab0c9ff1
• Download URL:
  https://stacks.cdc.gov/view/cdc/217973/cdc_217973_DS1.pdf
• File Type:
  [PDF - 68.44 KB ]