Neurological Effects of Organophosphates on Farm Workers

Details

• Personal Author:
  Anger K ; Checkoway, Harvey ; Claypoole K ; Engle L ; Fenske R ; Keifer MC ; Robinson L ; Rosenstock, Linda
• Description:
  The study determined if exposure to organophosphate pesticides (OPs) during apple thinning had a detectable effect on neurobehavioral performance and neurological function, and whether years of historical exposure to orchard thinning showed an effect on the same functions after recovery from any acute effects. Tests including World Health Organization Core Test Battery, memory tests, mood and neurological symptoms, acetylcholinesterase, vibration threshold, paraoxonase and nerve conduction tests were given to 137 farm workers at the end of the thinning season and after a 6-9 month exposure respite. Ninety workers were tested a second time. Recent and life long exposure to OPs by the workers did not adversely affect their performance in the battery tests. Acetylcholinesterase activity as a measure of physiological effect of exposure inversely correlated with the reporter recent exposure. The Peabody Picture Vocabulary test correlated highly with reported years of education and frequently correlated with neurobehavioral performance. [Description provided by NIOSH]
• Subjects:
  Agriculture Cholinesterase Inhibitors Farmers Insecticides Nervous System Nervous System Diseases Occupational Health Organophosphates Safety
• Keywords:
  Acetylcholinesterase Agricultural-chemicals Agricultural-workers Cholinesterase-inhibitors Humans Neurological-diseases Neuromuscular-system-disorders Neurophysiological-effects Neurophysiology Neurotoxic-effects Neurotoxins Organo-phosphorus-compounds Organo-phosphorus-pesticides Pesticide-residues Pesticides Pesticides-and-agricultural-chemicals Surveillance-programs

  More +
• Series:
  Grant Final Reports
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Final Grant Report
• Place as Subject:
  Georgia ; OSHA Region 10 ; OSHA Region 4 ; Washington
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  OEP - Office of Extramural Programs
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-17
• NIOSHTIC Number:
  nn:20000936
• NTIS Accession Number:
  PB2001-100743
• Citation:
  NIOSH 2000 Jan; :1-17
• Federal Fiscal Year:
  2000
• NORA Priority Area:
  Work Environment And Workforce: Special Populations
• Performing Organization:
  Occupational Medicine Program, Departments of Medicine and Environmental Health, University of Washington, Ninth Ave., Seattle, Washington 98104
• Peer Reviewed:
  False
• Start Date:
  19930901
• Source Full Name:
  National Institute for Occupational Safety and Health
• End Date:
  19970831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:a2af8033467d40435927238d982e58abe43519e33d8fb7c00d8edff13ce31fe1667192375ce6653a51d2185c29e64339513297fa7d0d877945b00df9362d7c5f
• Download URL:
  https://stacks.cdc.gov/view/cdc/217966/cdc_217966_DS1.pdf
• File Type:
  [PDF - 810.54 KB ]