Biological Monitoring of Methanol Exposure, Final Performance Report, October 17, 1996

Details

• Personal Author:
  Franzblau, Alfred
• Description:
  Reproducible and noninvasive methods for biologically monitoring occupational methanol (67561) exposures were developed, and the impact of exercise and cutaneous methanol exposures on such indices was evaluated. Formic-acid (64186) in urine was used as a quantitative biological exposure indicator for exposure of humans to methanol via the inhalation route and via the cutaneous route. Methanol in urine was evaluated as a quantitative biological exposure indicator for human exposures to methanol. The use of methanol in end expired air was evaluated as a quantitative biological exposure indicator. The effects of exercise, monitored by the ventilation rate, on formic-acid in urine, methanol in urine and methanol in end expired air were evaluated in humans exposed to methanol via the inhalation route. Formic-acid was a very poor biological indicator of methanol exposure in the range of the permissible exposure and threshold limit values. Regarding the use of methanol in urine as a biological index indicated that all methanol based parameters were approximately linearly related to exposure concentrations, but there was considerable inter-individual variations in all measured parameters. Blood and breath concentrations of methanol were disproportional for varying periods of time during and following cessation of methanol exposure, depending on the route of exposure. In settings where both dermal and inhalation exposures can occur, it would be necessary to wait at least 2 hours to collect breath specimens following cessation of methanol exposure. [Description provided by NIOSH]
• Subjects:
  Occupational Health Respiratory System Safety Skin Skin Absorption
• Keywords:
  Alcohols Biological-monitoring Grants-other Inhalation-studies NIOSH-Grant Skin-absorption Skin-exposure Urinalysis;
• Series:
  Grant Final Reports
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Final Grant Report
• Place as Subject:
  Michigan ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  OEP - Office of Extramural Programs
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-5
• NIOSHTIC Number:
  nn:00241066
• NTIS Accession Number:
  PB98-137755
• Citation:
  Department of Environmental and Industrial Health, School of Public Health, University of Michigan 1996 Oct; :1-5
• Contact Point Address:
  Environmental & Indust Health University of Michigan 1420 Washington Heights Ann Arbor, MI 48109-2029
• CAS Registry Number:
  Formic acid (CAS RN 64-18-6) ; Methanol (CAS RN 67-56-1)
• Federal Fiscal Year:
  1997
• NORA Priority Area:
  Other Occupational Concerns ; Grants Other
• Performing Organization:
  University of Michigan at Ann Arbor, Ann Arbor, Michigan
• Peer Reviewed:
  False
• Start Date:
  19930201
• Source Full Name:
  Department of Environmental and Industrial Health, School of Public Health, University of Michigan
• End Date:
  19960731
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:645b0272b8468a4b1d0644c85ac9e550e55c014270bacceb56d0be6cb6271e77d3c9dd8c1bf3814725eaf34270e68abf1c25ba6e0e39134e7488ea9e7ddf92ac
• Download URL:
  https://stacks.cdc.gov/view/cdc/217945/cdc_217945_DS1.pdf
• File Type:
  [PDF - 379.91 KB ]