Time-Related Factors in Radiation-Cancer Dose Response

Details

• Personal Author:
  Richardson DB ; Wing SB
• Description:
  The effects of low level, external exposure to ionizing radiation on the mortality of workers at Oak Ridge National Laboratory (ORNL) were investigated. The retrospective cohort study included 14,095 ORNL workers hired between 1943 and 1972 and followed through 1990. The focus on the analysis was on time related factors which influenced the association between all cancer mortality rates and cumulative external radiation dose. The data indicated that the cumulative dose received after age 45 strongly predicted all cancer mortality among these workers under a range of lag assumptions, and provided estimates of similar magnitude for lung cancer mortality and mortality from cancers other than lung. The cumulative dose received at older ages was more strongly associated with subsequent cancer mortality than lifetime cumulative dose. The strong evidence of a dose response relationship and the substantial magnitude of this association suggest that by considering age at exposure a smaller, more relevant time period of exposure can be identified. The authors suggest that if the effects of low level radiation do indeed increase with age, then differences in radiosensitivity need to be incorporated into considerations of radiation protection, medical uses of radiation, and the implications of industrial and military applications of nuclear technologies. [Description provided by NIOSH]
• Subjects:
  Age Factors Epidemiology Lung Lung Diseases Neoplasms Occupational Exposure Occupational Health Radiation Respiratory System Respiratory Tract Diseases Risk Assessment Safety

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• Keywords:
  Age-factors Cancer-rates Humans Ionizing-radiation Lung-cancer NIOSH-Grant Nuclear-radiation Occupational-exposure Pulmonary-system-disorders Radiation-exposure Risk-analysis

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• Series:
  Grant Final Reports
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Final Grant Report
• Place as Subject:
  North Carolina ; OSHA Region 4
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  OEP - Office of Extramural Programs
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-229
• NIOSHTIC Number:
  nn:00240645
• NTIS Accession Number:
  PB98-130925
• Citation:
  Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, North Carolina 1997 Aug; :1-229
• Contact Point Address:
  Epidemiology University of North Carolina Cb#7400 Mcgavran-Greenberg HAl Chapel Hill, NC 27599-7400
• Federal Fiscal Year:
  1997
• Performing Organization:
  University of North Carolina Chapel Hill, Chapel Hill, North Carolina
• Peer Reviewed:
  False
• Start Date:
  19950701
• Source Full Name:
  Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, North Carolina
• End Date:
  19970630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:5c7b2bc4aea758651394d93e91bb84031bf0fe0ce914ca0c70bd3262a5b9ce1c378cc2a561b9f57300f00595deb2cc63855083b2d2588cf2ea05b05e21186e1b
• Download URL:
  https://stacks.cdc.gov/view/cdc/217941/cdc_217941_DS1.pdf
• File Type:
  [PDF - 7.02 MB ]