Pulmonary Effects of Machining Fluid Aerosols

Details

• Personal Author:
  Gordon T
• Description:
  The relative toxicity of three major classes of machining fluids (soluble, synthetic and semisynthetic) was compared in an animal model of pulmonary injury and inflammation. Significant differences in toxicity were noted in guinea-pigs after a single 3 hour exposure suggesting that various types of machining fluids may have inherent differences in toxicity in the workplace. Greater toxicity was noted in guinea-pigs exposed for 3 hours to used machining fluid aerosols compared to aerosols of unused fluids. Physicochemical properties of machining fluids were also found to contribute to adverse pulmonary effects. Little to no pulmonary injury or inflammation was noted in guinea-pigs exposed to 5mg/m3 used machining fluid aerosols for 30 days. Three daily exposures of rats to 20mg/m3 used machining fluid aerosols produced a significant increase in stored mucosubstances in the epithelial lining of the intrapulmonary airways and the nasal septum. These findings suggest that irritant components of machining fluids can contribute to the increase in sputum and chronic bronchitis reported for workers exposed to machining fluid aerosols. [Description provided by NIOSH]
• Subjects:
  Hazardous Substances Laboratories Occupational Health Respiratory System Respiratory Tract Diseases Safety
• Keywords:
  Cutting-oils Inhalation-studies Laboratory-animals NIOSH-Grant Pulmonary-system-disorders Respiratory-system-disorders Toxic-effects
• Series:
  Grant Final Reports
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Final Grant Report
• Place as Subject:
  Iowa ; New York ; OSHA Region 2 ; OSHA Region 7
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  OEP - Office of Extramural Programs
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-21
• NIOSHTIC Number:
  nn:00238188
• NTIS Accession Number:
  PB97-206353
• Citation:
  Department of Internal Medicine, University of Iowa, Iowa City, Iowa 1997 Jan; :1-21
• Contact Point Address:
  Environmental Medicine New York University Medical Ct Long Meadow Road Tuxedo, NY 10987
• Federal Fiscal Year:
  1997
• Performing Organization:
  New York University, New York, New York
• Peer Reviewed:
  False
• Start Date:
  19930901
• Source Full Name:
  Department of Internal Medicine, University of Iowa, Iowa City, Iowa
• End Date:
  20050929
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:d8e7ca6165a16feb66ffd9361bf1d0bbf91ce0bc6e04aad7526bc25fa86022a0a8f75a5f5dbe43551f6bfbe4c2623499d600066fb7bd04718482d5bf5055a2a3
• Download URL:
  https://stacks.cdc.gov/view/cdc/217916/cdc_217916_DS1.pdf
• File Type:
  [PDF - 920.07 KB ]