Vanadium Toxicity: A Study of Mechanisms

Details

• Personal Author:
  Klevay LM
• Description:
  The purpose of the investigation was to produce marginal chromium (7440473) deficiencies in rats through manipulation of their diets. After this deficiency was produced, small amounts of vanadium (7440622) compounds were added to the drinking water of the animals and the effects of this addition were studied. One group of rats were fed a diet deficient in chromium with 5 micrograms of chromium/milliliter drinking water. No increase was noted in the glucose metabolism on this diet. A second group received 10 micrograms chromium/milliliter drinking water. No differences were noted between the group supplemented with chromium and the control group, or the group supplemented with vanadium at 5 micrograms vanadium/milliliter water and the control group or the groups supplemented with chromium and vanadium, concerning measurements of cholesterol in plasma. The findings were at variance with other published reports and indicated that only under certain circumstances did exposure to vanadium and chromium cause changes in the metabolism of cholesterol. The author suggests that this experimental approach is probably not appropriate for the study of vanadium intoxication in industrial settings. However, this approach may be useful in studies on the pathogenesis of atherosclerotic heart disease. [Description provided by NIOSH]
• Subjects:
  Cardiovascular Diseases Cardiovascular System Diet Energy Metabolism Laboratories Occupational Health Safety Vanadium Compounds
• Keywords:
  Cardiovascular-system-disorders Dietary-effects Grants-other Laboratory-animals Metabolic-study NIOSH-Grant Vanadium-compounds
• Series:
  Grant Final Reports
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Final Grant Report
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  OEP - Office of Extramural Programs
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-3
• NIOSHTIC Number:
  nn:00190675
• NTIS Accession Number:
  PB90-129412
• Citation:
  Report 1973 Feb; :1-3
• Contact Point Address:
  Environmental Health Kettering Laboratory Eden & Bethesda Avenues Cincinnati, Ohio 45219
• CAS Registry Number:
  Chromium (CAS RN 7440-47-3) ; Vanadium (CAS RN 7440-62-2)
• Federal Fiscal Year:
  1973
• NORA Priority Area:
  Grants Other
• Performing Organization:
  University of Cincinnati, Cincinnati, Ohio
• Peer Reviewed:
  False
• Start Date:
  19710401
• Source Full Name:
  Report
• End Date:
  19730331
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:532e5c667c46ce9b6779d6a92f747112ae4d857a24d0555caf0664faf6c7b39852d564c18a85a8bc3c2a3b0ed8965949c03f337950d7580e64fc2750dd9ec834
• Download URL:
  https://stacks.cdc.gov/view/cdc/217764/cdc_217764_DS1.pdf
• File Type:
  [PDF - 149.78 KB ]