Cutaneous Responses to Topical Methyl Nicotinate in Black, Oriental and Caucasian Subjects

Details

• Personal Author:
  Gean CJ ; Guy RH ; Maibach HI ; Tur E
• Description:
  Assessments were made of cutaneous responses to topically applied methyl-nicotinate (93607) (MN) on black, oriental, and Caucasian subjects to determine if racial differences had any part to play in percutaneous absorption and microcirculatory sensitivity. Both visual and laser Doppler velocimetry evaluations were made of the MN induced vasodilatation. Specific assessment was made of the diameter of the maximum visually perceptible erythematous area, the area under the erythematous diameter versus time curve, the maximum laser Doppler velocimetry response, and the area under the laser Doppler velocimetry response versus time curve. For all subjects each of the measures above mentioned was dependent on the dose of MN applied with the exception of the maximum laser Doppler velocimetry response. The authors conclude that although some racial differences did appear to exist in response to topical MN, the perception of these distinctions may depend on the method of measurement. [Description provided by NIOSH]
• Subjects:
  Dermatitis Occupational Health Race Factors Safety Skin Skin Absorption
• Keywords:
  NIOSH-Grant Racial-factors Skin-absorption Skin-exposure
• Series:
  Grant Final Reports
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Final Grant Report
• Place as Subject:
  California ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  OEP - Office of Extramural Programs
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-23
• NIOSHTIC Number:
  nn:00182747
• NTIS Accession Number:
  PB89-129910
• Citation:
  Departments of Pharmacy, Pharmaceutical Chemistry and Dermatology, Schools of Pharmacy and Medicine, University of California, San Francisco, California, 1987 Dec; :1-23
• Contact Point Address:
  Pharmacy University of California 926 Medical Sciences Building San Francisco, Calif 94143
• CAS Registry Number:
  Methyl nicotinate (CAS RN 93-60-7)
• Federal Fiscal Year:
  1988
• NORA Priority Area:
  Disease and Injury: Allergic and Irritant Dermatitis
• Performing Organization:
  University of California San Francisco, San Francisco, California
• Peer Reviewed:
  False
• Start Date:
  19840928
• Source Full Name:
  Departments of Pharmacy, Pharmaceutical Chemistry and Dermatology, Schools of Pharmacy and Medicine, University of California, San Francisco, California
• End Date:
  19871231
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:f71c8ad15055b3cf4f22dfa577c0ca75b558d5a0e5052f3f0ffefd3f96ba4f7817913f675d0b42a3c45b2679c88fbc483eba7363e7dde3fbe5f27fbba90c0644
• Download URL:
  https://stacks.cdc.gov/view/cdc/217746/cdc_217746_DS1.pdf
• File Type:
  [PDF - 703.75 KB ]