Principles of Skin Permeability Relevant to Chemical Exposure

Details

• Personal Author:
  Guy RH ; Hadgraft J
• Description:
  Biological and physicochemical parameters which determine the rate and extent of chemical penetration across the human skin were identified. Such exposures may represent a significant occupational hazard. Anatomical features of the skin that control the barrier to absorption were reviewed. The interaction of the physiological parameters with the physicochemical properties of the dermally contacting chemical were discussed to determine the kinetics and degree of penetration which will be accomplished. The relationship between chemical structure and activity and penetration of the skin was reviewed for n-alkanols, phenols, phenylboronic acids, steroids, nicotinic-acid esters, alkanoic acids, polynuclear aromatics, and nonsteroidal antiinflammatory drugs. Using skin absorption data for the forearm alone it is possible to calculate relative body exposures; to model this process of skin absorption effectively is a complex undertaking. The simplest treatment involves the use of Fick's laws of diffusion and an estimation of total body burden following a dermal exposure. Another approach based on the physicochemical properties of the penetrant was also discussed. [Description provided by NIOSH]
• Subjects:
  Dermatitis Occupational Health Safety Skin
• Keywords:
  Models NIOSH-Grant Skin-exposure Skin-sensitivity
• Series:
  Grant Final Reports
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Final Grant Report
• Place as Subject:
  California ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  OEP - Office of Extramural Programs
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-54
• NIOSHTIC Number:
  nn:00182726
• NTIS Accession Number:
  PB89-130009
• Citation:
  Departments of Pharmacy and Pharmaceutical Chemistry, Schools of Pharmacy and Medicine, University of California, San Francisco, California, 1987 Dec; :1-54
• Contact Point Address:
  Pharmacy University of California 926 Medical Sciences Building San Francisco, Calif 94143
• Federal Fiscal Year:
  1988
• NORA Priority Area:
  Disease and Injury: Allergic and Irritant Dermatitis
• Performing Organization:
  University of California San Francisco, San Francisco, California
• Peer Reviewed:
  False
• Start Date:
  19840928
• Source Full Name:
  Departments of Pharmacy and Pharmaceutical Chemistry, Schools of Pharmacy and Medicine, University of California, San Francisco, California
• End Date:
  19871231
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:0dd64c5f5c43f5f4d5d68a91e0836a9d27c097c12c9fa86bb15a5f8f74a96567fa34a1426b64f4e027a174776bafb70b659eb67e314db70449308e6e70322851
• Download URL:
  https://stacks.cdc.gov/view/cdc/217744/cdc_217744_DS1.pdf
• File Type:
  [PDF - 1.44 MB ]