Methyl Methacrylate Induced Changes in CNS Activity

Details

• Personal Author:
  Innes DL
• Description:
  Experiments were performed to determine if methyl-methacrylate (80626) (MMA) monomer vapor in air caused central nervous system (CNS) changes in exposed rats. Rats were exposed to 400 parts per million (ppm) MMA vapor for 60 minutes. The only significant changes to develop occurred in the lateral hypothalamic and ventral hippocampal nuclei. Several substudies conducted to better understand these results suggested that the changes in the hippocampal neuronal firing rates were related to the perception of the MMA odor and dependent on the presence of an intact nervous connection to the receptors in the nose. In a subchronic study animals were exposed for 2 to 10 weeks to 400ppm MMA vapor. No consistent long term changes in neuronal activity were detected. However, a decrease in neuronal activity was detected during the first week of exposure. In another study the exposure levels of MMA ranged from 50 to 800ppm. The lateral hypothalamic and ventral hippocampal nuclei responded as before, but not at the 50ppm level. From this data the author concludes that the threshold exposure concentration for the observed effects are the same as or slightly less than the current threshold limit value for MMA vapor in the workplace. [Description provided by NIOSH]
• Subjects:
  Hazardous Substances Laboratories Nervous System Nervous System Diseases Occupational Health Plastics Respiratory System Safety Solvents
• Keywords:
  Central-nervous-system Inhalation-studies Laboratory-animals Nervous-system-disorders NIOSH-Grant Plastics-industry Toxic-effects Vapors
• Series:
  Grant Final Reports
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Final Grant Report
• Place as Subject:
  OSHA Region 3 ; Pennsylvania
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  OEP - Office of Extramural Programs
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-10
• NIOSHTIC Number:
  nn:00181017
• NTIS Accession Number:
  PB88-247648
• Citation:
  Department of Physiology and Biophysics, Temple University, Philadelphia, Pennsylvania, Terminal Progress Report 1980 Jan; :1-10
• Contact Point Address:
  Physiology and Biophysics Temple University Physiology and Biophysics Dept Philadelphia, PA 19140
• CAS Registry Number:
  2-Propenoic acid, 2-methyl-, methyl ester (CAS RN 80-62-6)
• Federal Fiscal Year:
  1980
• Performing Organization:
  Temple University, Philadelphia, Pennsylvania
• Peer Reviewed:
  False
• Start Date:
  19780301
• Source Full Name:
  Department of Physiology and Biophysics, Temple University, Philadelphia, Pennsylvania, Terminal Progress Report
• End Date:
  19800229
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:9989e1485e45bebb8c8d87b1e64b1b525f8db90efc1465b8e50e5ad80edaa35825acdb27bbdafe2a14e453e3a4a3027492d2800474bc5d27cba36ac8d8aacdbc
• Download URL:
  https://stacks.cdc.gov/view/cdc/217734/cdc_217734_DS1.pdf
• File Type:
  [PDF - 3.80 MB ]