Final Report on the Project Aerosol Deposition in the Human Respiratory System

Details

• Personal Author:
  Yu CP
• Description:
  Attempts were made to develop mathematical models for the deposition of aerosols in the human respiratory system. Expressions were obtained for the mean deposition efficiency for nasal inspiration, nasal expiration and mouth inspiration. A determination was made of statistical properties associated with each deposition efficiency due to intersubject and intrasubject variabilities. Expressions were then derived for head deposition with combined nose and mouth breathing. In the lung, deposition is a result primarily of impaction, sedimentation, and diffusion. While there was no adequate model for impaction, several deposition formulae for sedimentation have been derived as well as ones for diffusion. Studies have also been made of the particle charge effect, as the electrostatic image force on a particle contributes to its deposition. There is, however, a threshold charge per particles below which the particle charge has no effect on deposition. Deposition data on ultrafine particles is scarce due to the difficulties in conducting proper experiments. Studies have also been concerned with the deposition of large particles, the deposition of polydisperse aerosols, the effect of different airway structures, statistical models, and clearance in the tracheobronchial tree. [Description provided by NIOSH]
• Subjects:
  Aerosols Inhalation Exposure Lung Occupational Health Particulate Matter Respiratory System Safety
• Keywords:
  Aerosol-particles Inhalants Inhalation-studies Lung-function Mathematical-models NIOSH-Grant Particulates Pulmonary-system
• Series:
  Grant Final Reports
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Final Grant Report
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  OEP - Office of Extramural Programs
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-14
• NIOSHTIC Number:
  nn:00181008
• NTIS Accession Number:
  PB88-247614
• Citation:
  State University of New York, Buffalo, New York, 1987 Jan; :1-14
• Contact Point Address:
  Engineering Science S U N Y - at Buffalo Dept of Engineering Science Buffalo, N Y 14214
• Federal Fiscal Year:
  1987
• Performing Organization:
  State University of New York at Buffalo, Buffalo, New York
• Peer Reviewed:
  False
• Start Date:
  19791201
• Source Full Name:
  State University of New York, Buffalo, New York
• End Date:
  19861130
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:3d9fbc73af89aad6e9824c8111e65868935a568b10ee5de22891c6f457d605732a4b6c7d6ab8f9ca9ea236b9c14059946f829b8d5e41cfbbb773bf16289b7384
• Download URL:
  https://stacks.cdc.gov/view/cdc/217731/cdc_217731_DS1.pdf
• File Type:
  [PDF - 4.89 MB ]