Mesothelioma in Relation to Asbestos, Terminal Progress Report

Details

• Personal Author:
  Smith WE ; Smith WE
• Description:
  The carcinogenicity of asbestos (1332214) was examined in LVGLAK- hamsters. Hamsters were given a single injection of 0.5 milliliter of a suspension of 1 of 23 preparations of asbestos or other minerals into the right pleural cavity. Animals were followed for 650 to 700 days after injection or until death. Necropsies were performed. Thoracic contents were examined microscopically and histologically. Presence or absence of pleural adhesions and their character, plaques, thrombi, or other pathologies were noted. Mesotheliomas were found after injection of soft chrysotile (12001295), harsh chrysotile, amosite (12172735), diatomaceous earth, crocidolite (12001284), anthophyllite (16829439), nickel (7440020) powder, and microquartz fibers. Tumors appeared more quickly with harsh chrysotile than with the soft variety. Fibrogenic and carcinogenic responses to chrysotile, amosite, and crocidolite were reduced with reductions in dose. At a dose of 1 milligram, tumors were found only in response to crocidolite. Reduction of fiber length of chrysotile reduced fibrogenic responses and eliminated carcinogenic responses. Electron micrography showed phagocytosis of asbestos fibers by macrophages and by epithelial cells after chrysotile injection. [Description provided by NIOSH]
• Subjects:
  Animals Carcinogens Clinical Laboratory Techniques Dust Hazardous Substances Laboratories Occupational Health Safety
• Keywords:
  Animal-studies Clinical-techniques Dust-exposure Laboratory-testing NIOSH-Grant Testing-equipment Toxic-effects
• Series:
  Grant Final Reports   ; Grant Final Reports  
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Final Grant Report ; Final Grant Report
• Place as Subject:
  New Jersey ; Ohio ; OSHA Region 2 ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH) ; National Institute for Occupational Safety and Health (NIOSH)
• Division:
  OEP - Office of Extramural Programs ; OEP - Office of Extramural Programs
• Topic:
  Workplace Safety & Health ; Workplace Safety & Health
• Location:
  North America ; North America
• Pages in Document:
  1-21
• NIOSHTIC Number:
  nn:00134964
• NTIS Accession Number:
  PB84-241603
• Citation:
  NIOSH 1971 Jan; :1-21
• CAS Registry Number:
  Amosite asbestos (CAS RN 12172-73-5) ; Asbestos (CAS RN 1332-21-4) ; Chrysotile (CAS RN 12001-29-5) ; Crocidolite asbestos (CAS RN 12001-28-4) ; Magnesio-anthophyllite (CAS RN 16829-43-9) ; Nickel (CAS RN 7440-02-0) ; Amosite asbestos (CAS RN 12172-73-5) ; Asbestos (CAS RN 1332-21-4) ; Chrysotile (CAS RN 12001-29-5) ; Crocidolite asbestos (CAS RN 12001-28-4) ; Magnesio-anthophyllite (CAS RN 16829-43-9) ; Nickel (CAS RN 7440-02-0)
• Federal Fiscal Year:
  1971
• Performing Organization:
  Fairleigh Dickinson University
• Peer Reviewed:
  False
• Start Date:
  19660301
• Source Full Name:
  NIOSH, U.S. Department of Health, Education, and Welfare, Cincinnati, Ohio
• End Date:
  19700831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:fa0c4c66798f352757234f31d1e2d909865e19b2dd24469f6df6cb11d04bcd01c26a1988e6ccb7baee0d1c5a68a0e1e2aac2e773acbeff19de777bc51b56971b
• Download URL:
  https://stacks.cdc.gov/view/cdc/217716/cdc_217716_DS1.pdf
• File Type:
  [PDF - 728.06 KB ]