Mechanism of Action: Carcinogenic O-Methylarylamines

Details

• Personal Author:
  Fiala ES ; Hecht SS ; Weisburger JH
• Description:
  The carcinogenicity of 3,2'-dimethyl-4-aminobiphenyl (13394860) (DMAB) and 3-methyl-2-naphthylamine (10546244) (MNA) was investigated in F344-rats, Charles-River-CDF-rats, Syrian-golden- hamsters, and guinea-pigs. Mutagenicity of aniline (62533) derivatives, MNA, DMAB, and ortho-toluidine (95534) was determined in Salmonella-typhimurium strains TA-100, TA-1535, and TA-1538, with or without rat liver S9 fraction. Rats and hamsters were given subcutaneous injections of MNA or DMAB for various periods then killed and necropsied. Rats were compared to hamsters in terms of susceptibility to DMAB carcinogenesis. Tritiated DMAB was given to hamsters and F344-rats. Bile was collected in cannulated animals and urine and feces were collected from nonoperated animals. DMAB produced mainly urinary bladder tumors in hamsters; MNA was less active, but caused local sarcoma at the injection site. Treatment with disulfiram (97778) decreased DMAB carcinogenicity in the small intestine in hamsters, while rats developed bladder tumors. No effect was seen on colon cancers. Prostate carcinomas occurred in male rats given DMAB but none were seen in hamsters. In Salmonella, compounds having a methyl group ortho to the amine were more mutagenic. Greater amounts of DMAB were excreted in the bile of rats than in hamsters. Hamsters excreted DMAB in urine, whereas rats did not. [Description provided by NIOSH]
• Subjects:
  Animals Carcinogens Cytotoxins Occupational Health Poisoning Safety Urogenital Diseases Urogenital System
• Keywords:
  Animal-studies Bladder-disorders Cytotoxic-effects Industrial-chemicals NIOSH-Grant Poisons Safety-research
• Series:
  Grant Final Reports
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Final Grant Report
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  OEP - Office of Extramural Programs
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-39
• NIOSHTIC Number:
  nn:00133231
• NTIS Accession Number:
  PB84-238310
• Citation:
  American Health Foundation, Hammond House Road, 1982 Jan; :1-39
• CAS Registry Number:
  3,2′-Dimethyl-4-aminobiphenyl (CAS RN 13394-86-0) ; 3-Methyl-2-naphthalenamine (CAS RN 10546-24-4) ; Aniline (CAS RN 62-53-3) ; o-Toluidine (CAS RN 95-53-4) ; Tetraethylthiuram disulfide (CAS RN 97-77-8)
• Federal Fiscal Year:
  1982
• Performing Organization:
  American Health Foundation Hammond House Road Valhalla, N Y 10595
• Peer Reviewed:
  False
• Start Date:
  19751201
• Source Full Name:
  American Health Foundation, Hammond House Road
• End Date:
  19811130
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:73a260d28472c09bf7c4e27cc7e2d44007e30d9ee6845b1c2774be331641b2f6e6b33d6fd41b336975bc76fddfc37579a434de86baa0a7e503b7cb6e5bb455df
• Download URL:
  https://stacks.cdc.gov/view/cdc/217709/cdc_217709_DS1.pdf
• File Type:
  [PDF - 1.39 MB ]