Acrylonitrile Pharmacodynamics and Mutagenesis

Details

• Personal Author:
  Wolff MS
• Description:
  The elimination routes and metabolism of acrylonitrile (107131) (AN) were investigated in the rat by studying kinetics in the blood following administration of 5 to 60 milligrams per kilogram doses. Blood samples were obtained at 5 to 10 minute intervals, and AN concentrations were measured using gas chromatography. AN concentrations in urine, feces, fat, and liver also were obtained where possible. Efforts to characterize possible metabolites were unsuccessful. AN had biphasic kinetic elimination from blood with half lives of approximately 10 to 50 minutes for the fast and slow rate constants, respectively. Both rates were dose dependent, and both were observed in liver tissue in-vitro. Induction with phenobarbital did not change the pharmacokinetic curve. Total AN measured in feces, urine, and tissues, represented only 3 to 30 percent of the administered dose, even at very short intervals following administration. AN did not appear to accumulate in the body, due to rapid, unchanged excretion in urine and feces and to rapid metabolism. The author concludes that the pharmacodynamics of AN are complex with at least two major metabolic pathways. [Description provided by NIOSH]
• Subjects:
  Chromatography Energy Metabolism Hematologic Tests Laboratories Mutagens Neoplasms Nervous System Occupational Health Safety
• Keywords:
  Body-retention Chromatographic-analysis Dose-response Hematology Laboratory-animals Malignant-neoplasms Metabolism Mutagenesis Neurotoxic-effects NIOSH-Grant
• Series:
  Grant Final Reports
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Final Grant Report
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  OEP - Office of Extramural Programs
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-8
• NIOSHTIC Number:
  nn:00092785
• NTIS Accession Number:
  PB88-246947
• Citation:
  Environmental Science Laboratory, Mount Sinai School of Medicine of the City University of New York, New York, New York 1977 Jul; :1-8
• Contact Point Address:
  Community Medicine Mount Sinai School of Medicine Fifth Avenue and 100Th Street New York, N Y 10029
• CAS Registry Number:
  Acrylonitrile (CAS RN 107-13-1)
• Federal Fiscal Year:
  1977
• NORA Priority Area:
  Neurotoxic Disorders ; Neurotoxic Effects
• Performing Organization:
  Mount Sinai School of Medicine, New York, New York
• Peer Reviewed:
  False
• Start Date:
  19770701
• Source Full Name:
  Environmental Science Laboratory, Mount Sinai School of Medicine of the City University of New York, New York, New York
• End Date:
  19790630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:cac3ddab10380b141d2996bcff5c4edb953aec0ce6285537ece0955e4255f7891f14eae77f617bc82cb6cb220677a1e96f6d5805812227450a72efd58cc7a6b6
• Download URL:
  https://stacks.cdc.gov/view/cdc/217702/cdc_217702_DS1.pdf
• File Type:
  [PDF - 197.97 KB ]