Design Considerations for Reducing Sample Loss in Microfluidic Paper-Based Analytical Devices

Details

• Personal Author:
  Henry CS ; Kelly SP ; Meredith NA ; Nguyen MP
• Description:
  The field of microfluidic paper-based analytical devices (uPADs) is most notably characterized by portable and low-cost analysis; however, struggles to achieve the high sensitivity and low detection limits needs required for many environmental applications hinder widespread adoption of this technology. Loss of analyte to the device material represents an important problem impacting sensitivity. Critically, we found that at least 50% of a Ni(II) sample is lost when being transported down a 30 mm paper channel that is representative of structures commonly found in uPADs. In this work, we report simple strategies such as adding a waste zone, enlarging the detection zone, and using an elution step to increase device performance. A uPAD combining the best performing functionalities led to a 78% increase in maximum signal and a 28% increase in sensitivity when transporting Ni(II) samples. Using the optimized uPAD also led to a 94% increase in maximum signal for Mn(II) samples showing these modifications can be applied more generally. [Description provided by NIOSH]
• Subjects:
  Environmental Exposure Environmental Monitoring Environmental Pollution Occupational Health Safety
• Keywords:
  Analytical Instruments Author Keywords: Microfluidic Paper-based Analytical Device (µPAD) Colorimetric Detection Detectors Device Fabrication Environmental Monitoring Environmental Pollution Equipment Design Sample Loss Sampling Equipment Wax Printing

  More +
• ISSN:
  0003-2670
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Arkansas ; Colorado ; OSHA Region 6 ; OSHA Region 8
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  20-25
• Volume:
  1017
• NIOSHTIC Number:
  nn:20055333
• Citation:
  Anal Chim Acta 2018 Aug; 1017:20-25
• Contact Point Address:
  Charles S. Henry, Department of Chemistry, Colorado State University, Fort Collins, Colorado 80523, United States
• Email:
  Chuck.Henry@colostate.edu
• Federal Fiscal Year:
  2018
• Performing Organization:
  Colorado State University, Fort Collins
• Peer Reviewed:
  True
• Start Date:
  20150901
• Source Full Name:
  Analytica Chimica Acta
• End Date:
  20190831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:05a199cd6cea365763d09fda6ce94a86972bad28bb4f02750e2830948d14edd3a1eba60a6aa8fdb3b3870b348874f35404817ede8d54bc0fdae8ecb403d71616
• Download URL:
  https://stacks.cdc.gov/view/cdc/217665/cdc_217665_DS1.pdf
• File Type:
  [PDF - 840.08 KB ]