Radio-Fluorogenic Gel Dosimetry with Coumarin

Details

• Personal Author:
  Bastow BP ; Connick WB ; Elson HR ; Fenichel H ; Lamba M ; Sandwall PA ; Spitz HB
• Description:
  Gel dosimeters are attractive detectors for radiation therapy, with properties similar to biological tissue and the potential to visualize volumetric dose distributions. Radio-fluorogenesis is the yield of fluorescent chemical products in response to energy deposition from ionizing radiation. This report shares the development of a novel radio-fluorogenic gel (RFG) dosimeter, gelatin infused with coumarin-3-carboxlyic acid (C3CA), for the quantification of imparted energy. Aqueous solutions exposed to ionizing radiation result in the production of hydroxyl free radicals through water radiolysis. Interactions between hydroxyl free radicals and coumarin-3-carboxylic acid produce a fluorescent product. 7-hydroxy-coumarin-3-carboxylic acid has a blue (445 nm) emission following ultra-violet (UV) to near UV (365-405 nm) excitation. Effects of C3CA concentration and pH buffers were investigated. The response of the RFG was explored with respect to strength, type, and exposure rate of high-energy radiation. Results show a linear dose response relationship independent of energy and type, with a dose-rate dependency. This report demonstrates increased photo-yield with high pH and the utility of gelatin-RFG for phantom studies of radiation dosimetry. [Description provided by NIOSH]
• Subjects:
  Occupational Health Radiation Dosimeters Safety
• Keywords:
  Author Keywords: Gel Dosimetry Dosimetry Luminescence Luminescent Dosimetry Nuclear Medicine Radiation Dosimetry Radiation Therapy Radio-fluorogenic Gel
• ISSN:
  2306-5354
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  53
• Volume:
  5
• Issue:
  3
• NIOSHTIC Number:
  nn:20055244
• Citation:
  Bioengineering 2018 Jul; 5(3):53
• Contact Point Address:
  Peter A. Sandwall, Department of Radiation Oncology, OhioHealth, 330 Glessner Ave., Mansfield, OH 44903, USA
• Email:
  pasandwall@gmail.com
• CAS Registry Number:
  Coumarin (CAS RN 91-64-5)
• Federal Fiscal Year:
  2018
• Performing Organization:
  University of Cincinnati
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Bioengineering
• End Date:
  20260630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:2c363d6f71c5f0ec32325e3792c49a170096c0cc345f222012bc3e39c9fc94ee9f0db0a2de085bd2a45dec562b17c10e08e8f8923dbd57dccc6c0df1e4d0c5b3
• Download URL:
  https://stacks.cdc.gov/view/cdc/217590/cdc_217590_DS1.pdf
• File Type:
  [PDF - 760.66 KB ]