Circulating Biomarkers of Neurotoxicity: Identifying Fluidic Endpoints Correlating with Central Nervous System Toxicity in a Rodent Model of Neurotoxicity

Details

• Personal Author:
  Aschner M ; Calligaro D ; Cuevas E ; Feruson SA ; Gong B ; Hanig J ; He Z ; Herr D ; Imam SZ ; Kallman M ; Lantz SM ; Law C ; Liachenko S ; MacMillan D ; Miller DB ; O'Callaghan JP ; Pardo ID ; Paule MG ; Pierson JB ; Raymick J ; Roberts R ; Robinson B ; Sarkar S ; Slikker W ; Smith A ; Somps C ; Tong W
• Description:
  Neurotoxicity has been linked to exposure to a number of common drugs and chemicals, yet efficient, predictive, and minimally-invasive methods to detect it are lacking. Fluid-based biomarkers such as those found in serum, plasma, urine, and cerebrospinal fluid (CSF) have great potential due to the relative ease of sampling, but at present, data on their expression and translation are lacking or inconsistent. Here, we present data on biomolecules that have some promise for detection and characterization of neurotoxicity induced by a single intraperitoneal injection of the known neurotoxic agent, trimethyltin (TMT). A single dose of TMT led to significant alterations in total oxidative stress markers, changes in lipid homeostasis, circulating interleukins and related factors, and markers of neuroinflammation. These findings provide an opportunity to explore the correlation of these fluid biomarkers with traditional neuropathology and magnetic resonance imaging (MRI) that serve to define TMT-induced neurotoxicity. Our data demonstrate a comprehensive correlation of TMT-induced neuropathology with several potential neurotoxicity biomarkers and MRI-based endpoints, findings suggestive of an involvement of specific pathways that can be assessed using peripheral fluids. [Description provided by NIOSH]
• Subjects:
  Biomarkers Body Fluids Immune System Laboratories Nervous System Occupational Health Safety Toxicology Urine
• Keywords:
  Biological Materials Body Fluids Central Nervous System Cerebrospinal Fluid Chemical Agent Detectors Dose Response Exposure Assessment Immune Reaction Laboratory Animals Laboratory Testing Lipid Disorders Magnetic Resonance Imaging MRI Neuropathology Neurotoxic Agents Neurotoxic Effects Neurotoxicology Oxidative Stress Serology Toxic Effects

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• ISSN:
  1096-6080
• Document Type:
  Text
• Genre:
  Abstract or Summary
• Place as Subject:
  Arkansas ; Connecticut ; District of Columbia ; Indiana ; Maryland ; New York ; North Carolina ; OSHA Region 1 ; OSHA Region 2 ; OSHA Region 3 ; OSHA Region 4 ; OSHA Region 5 ; OSHA Region 6 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  168
• Issue:
  1
• NIOSHTIC Number:
  nn:20055166
• Citation:
  Toxicologist 2019 Mar; 168(1)(Late-Breaking Suppl):180
• CAS Registry Number:
  Trimethylstannane (CAS RN 1631-73-8)
• Federal Fiscal Year:
  2019
• NORA Priority Area:
  Manufacturing
• Peer Reviewed:
  False
• Source Full Name:
  The Toxicologist. Society of Toxicology 58th Annual Meeting and ToxExpo, March 10-14, 2019, Baltimore, Maryland
• Supplement:
  Late-Breaking
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:6d9ef0624cdbea56000855e5dcccd9f4c82d552d19872f4ef9a3e9c5e9cf0013db504b80092ae53e445ad3c83570b2dd814e18dac530af61f8fc64c320d2d8a1
• Download URL:
  https://stacks.cdc.gov/view/cdc/217526/cdc_217526_DS1.pdf
• File Type:
  [PDF - 587.38 KB ]