Plasma Polychlorinated Biphenyl Concentrations and Immune Function in Postmenopausal Women

Details

• Personal Author:
  De Roos AJ ; McTiernan A ; Sheppard L ; Sjödin, Andreas ; Spector JT ; Ulrich CM ; Wener MH ; Wood B
• Description:
  Background: Polychlorinated biphenyl (PCB) exposure has been associated with non-Hodgkin lymphoma in several studies, and the immune system is a potential mediator. Objectives: We analyzed associations of plasma PCBs with immune function measures. We hypothesized that higher plasma PCB concentrations are associated with lower immune function cross-sectionally, and that increases in PCB concentrations over a one year period are associated with decreases in immune function. Methods: Plasma PCB concentrations and immune function [natural killer (NK) cell cytotoxicity and PHA-induced T-lymphocyte proliferation (PHA-TLP)] were measured at baseline and one year in 109 postmenopausal overweight women participating in an exercise intervention study in the Seattle, Washington (USA) area. Mixed models, with adjustment for body mass index and other potential confounders, were used to estimate associations of PCBs with immune function cross-sectionally and longitudinally. Results: Associations of PCBs with immune function measures differed across groups of PCBs (e.g., medium- and high-chlorinated and dioxin-like [mono-ortho-substituted]) and by the time frame for the comparison (cross-sectional vs. longitudinal). Higher concentrations of medium- and high-chlorinated PCBs were associated with higher PHA-TLP cross-sectionally but not longitudinally. The mean decrease in 0.5 ug/mL PHA-TLP/50.0 pmol/g-lipid increase in dioxin-like PCBs over one year was 51.6 (95% confidence interval 2.7, 100.5; P=0.039). There was no association between plasma PCBs and NK cytotoxicity. Conclusions: These results do not provide strong evidence of impaired cellular immunity from PCB exposure. Larger longitudinal studies with greater variability in PCB exposures are needed to further examine temporal associations of PCBs with immune function. [Description provided by NIOSH]
• Subjects:
  Cytotoxins Immune System Neoplasms Occupational Health Polychlorinated Biphenyls Safety Women
• Keywords:
  Author Keywords: Cytotoxicity Cellular Function Immune Function Immune System Lymphatic Cancer Lymphocyte Proliferation PCBs Persistent Organic Pollutants Polychlorinated Biphenyls
• ISSN:
  0013-9351
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Georgia ; OSHA Region 10 ; OSHA Region 4 ; Washington
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  174-180
• Volume:
  131
• NIOSHTIC Number:
  nn:20055153
• Citation:
  Environ Res 2014 May; 131:174-180
• Contact Point Address:
  June T. Spector, University of Washington, Department of Environmental & Occupational Health Sciences and Medicine, 4225 Roosevelt Way NE, Suite 100, Seattle, WA 98105, USA
• Email:
  spectj@uw.edu
• CAS Registry Number:
  1,1′-Biphenyl, chloro derivs. (CAS RN 1336-36-3)
• Federal Fiscal Year:
  2014
• Performing Organization:
  University of Washington
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Environmental Research
• End Date:
  20250630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:a113d16f52213096ad3a78b17ca8bcd80109ee79916732a7cfaca4f59bac3cbf62ded1578af6f1fbb36be7284ff79bd7589bed8d07490b92673cc986f8c3800f
• Download URL:
  https://stacks.cdc.gov/view/cdc/217514/cdc_217514_DS1.pdf
• File Type:
  [PDF - 309.81 KB ]