Traffic-Related Air Pollution and the Right Ventricle. The Multi-Ethnic Study of Atherosclerosis

Details

• Personal Author:
  Barr RG ; Bluemke DA ; Curl CL ; Hough CL ; Kaufman JD ; Kawut SM ; Leary PJ ; Lima JA ; Szpiro AA ; Van Hee VC
• Description:
  Rationale: Right heart failure is a cause of morbidity and mortality in common and rare heart and lung diseases. Exposure to traffic-related air pollution is linked to left ventricular hypertrophy, heart failure, and death. Relationships between traffic-related air pollution and right ventricular (RV) structure and function have not been studied. Objectives: To characterize the relationship between traffic-related air pollutants and RV structure and function. Methods: We included men and women with magnetic resonance imaging assessment of RV structure and function and estimated residential outdoor nitrogen dioxide (NO2) concentrations from the Multi-ethnic Study of Atherosclerosis, a study of individuals free of clinical cardiovascular disease at baseline. Multivariable linear regression estimated associations between NO2 exposure (averaged over the year prior to magnetic resonance imaging) and measures of RV structure and function after adjusting for demographics, anthropometrics, smoking status, diabetes mellitus, and hypertension. Adjustment for corresponding left ventricular parameters, traffic-related noise, markers of inflammation, and lung disease were considered in separate models. Secondary analyses considered oxides of nitrogen (NOx) as the exposure. Measurements and Main Results: The study sample included 3,896 participants. In fully adjusted models, higher NO2 was associated with greater RV mass and larger RV end-diastolic volume with or without further adjustment for corresponding left ventricular parameters, traffic-related noise, inflammatory markers, or lung disease (all P < 0.05). There was no association between NO2 and RV ejection fraction. Relationships between NOx and RV morphology were similar. Conclusions: Higher levels of NO2 exposure were associated with greater RV mass and larger RV end-diastolic volume. [Description provided by NIOSH]
• Subjects:
  Air Pollution Cardiovascular Diseases Cardiovascular System Cohort Studies Environmental Exposure Environmental Pollution Occupational Health Risk Assessment Risk Factors Safety
• Keywords:
  Air Pollution Author Keywords: Air Pollutants Automotive Emissions Cardiovascular Disease Cohort Studies Environmental Pollution Heart Disease Heart Ventricles Pulmonary Circulation Pulmonary Hypertension Risk Factors

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• ISSN:
  1073-449X
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Maryland ; Minnesota ; New York ; OSHA Region 10 ; OSHA Region 2 ; OSHA Region 3 ; OSHA Region 5 ; Pennsylvania ; Washington
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  189
• Issue:
  9
• NIOSHTIC Number:
  nn:20055139
• Citation:
  Am J Respir Crit Care Med 2014 May; 189(9):1093-1100
• Contact Point Address:
  Peter J. Leary, M.D., M.S., 1959 NE Pacific Street, University of Washington Medical Center, Division of Pulmonary and Critical Care Medicine, BB-1253 Health Sciences Center, Box 356522, Seattle, WA 98195-6522
• Email:
  learyp@uw.edu
• Federal Fiscal Year:
  2014
• Performing Organization:
  University of Washington
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  American Journal of Respiratory and Critical Care Medicine
• End Date:
  20250630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:6ce643c29b4e20da5ecbb4bdd125d46844c0b168056d155087376271686d6777e4913bd461587e795b61b210666e583ab571261bfcf250b97e1485610a94b08e
• Download URL:
  https://stacks.cdc.gov/view/cdc/217502/cdc_217502_DS1.pdf
• File Type:
  [PDF - 1.02 MB ]