Organochlorine Pesticides

Details

• Personal Author:
  Sullivan JB Jr ; Van Ert MD
• Description:
  Chlorinated hydrocarbon pesticides include DDT, DDE, and DDD; hexachlorocyclohexane (HCH) and isomers, including lindane (y-HCH); cyclodiene compounds; chlordecone, kelevan, and mirex; toxaphene; and dicofol and methoxychlor. The general toxicity of chlorinated hydrocarbon insecticides is central nervous system (CNS) stimulation or depression, depending on the compound and dose. Cyclodienes, HCHs, and toxaphene pesticides inhibit chloride influx in the CNS induced by gamma-aminobutyric acid (GABA) and thus interfere with GABA receptor function. This mechanism of inhibition is consistent with the clinical symptoms of CNS excitation and seizures seen in acute toxicity from organochlorine pesticides. In general, aldrin, dieldrin, lindane, toxaphene, endrin, and chlordane exposures via the oral, dermal, or inhalational route can cause seizures, muscle tremors, confusion, agitation, and coma as common manifestations. [Description provided by NIOSH]
• Subjects:
  Insecticides Occupational Health Safety Toxicology
• Keywords:
  Biological Effects Central Nervous System Chlorinated Hydrocarbons Exposure Assessment Health Effects Organochlorine Compounds Pesticides
• ISBN:
  9780683080278
• Publisher:
  Lippincott Williams & Wilkins
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Book
• Place as Subject:
  Arizona ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• NIOSHTIC Number:
  nn:20055092
• Citation:
  Clinical environmental health and toxic exposures, second edition. Sullivan JB Jr, Krieger GR eds. Philadelphia, PA: Lippincott Williams & Wilkins, 2001 Jun; :1057-1082
• Editor(s):
  Sullivan JB Jr; Krieger GR
• Federal Fiscal Year:
  2001
• Performing Organization:
  University of Arizona, Tucson
• Peer Reviewed:
  True
• Start Date:
  19950701
• Source Full Name:
  Clinical environmental health and toxic exposures, second edition
• End Date:
  20060630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:effd40dcc2c2b51006cc63583927fd9fe45633460f7e4b84da732cb4106b6a7c0bc5ae2ae8fddee9d19c828bd61fcce178ccaed01601523b3cd29f565288a53f
• Download URL:
  https://stacks.cdc.gov/view/cdc/217463/cdc_217463_DS1.pdf
• File Type:
  [PDF - 3.30 MB ]