Microbiome Changes as Markers of Exposure and Stress in Firefighters

Details

• Personal Author:
  Chandra H ; Golla V ; Hwang J ; Taylor R ; Yadav J
• Description:
  Firefighters have been identified to be at a higher occupational risk for several health disorders such as cancers, cardiovascular problems, respiratory disorders, diabetes etc. Firefighters are regularly exposed to smoke and heat involving inhalation of toxic chemicals such as PAHs and particulates as well as stressful work environment. All these factors have the potential to alter the consortium of human microflora (microbiome). In this investigation, we hypothesize that fire- associated exposure may cause stress and gut microbiome perturbations in firefighters which may interact with other prevailing physiological stress factors thereby increasing the risk for occupational diseases. We propose to compare the gut microbiome of firefighters from their fecal samples using 16S rRNA gene-based nextgen sequencing and identify the microbiome constituents associated with occupational PAH exposure. We will further correlate the microbiome changes with the exposure data and other metadata collected using a study questionnaire. Completion of the study is expected to identify specific gut microbiome constituents and changes associated with the firefighters. Further analysis will provide insights into role of microbiome dysbiosis in predisposing firefighters to occupational health risks. [Description provided by NIOSH]
• Subjects:
  Firefighters Heat Stress Disorders Hot Temperature Immune System Microbiology Occupational Health Safety
• Keywords:
  Fire Fighters Health Effects Heat Stress Immune Reaction Smoke Inhalation
• Publisher:
  University of Cincinnati
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Abstract or Summary
• Place as Subject:
  Kentucky ; Ohio ; OSHA Region 4 ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1
• NIOSHTIC Number:
  nn:20054934
• Citation:
  18th Annual Pilot Research Project Symposium, University of Cincinnati Education and Research Center, October 5-6, 2017, Cincinnati, Ohio. Cincinnati, OH: University of Cincinnati, 2017 Oct; :1
• Email:
  harish.chandra@uc.edu
• Federal Fiscal Year:
  2018
• Performing Organization:
  University of Cincinnati
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  18th Annual Pilot Research Project Symposium, University of Cincinnati Education and Research Center, October 5-6, 2017, Cincinnati, Ohio
• End Date:
  20260630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:1e4b24154460446608c498b1995662f50c4538e4c0dc369ee0a86953f50814182f6826e7e590973aa733fe4a0b0cb49116077c5b78cbaf42afe5409b25a660db
• Download URL:
  https://stacks.cdc.gov/view/cdc/217341/cdc_217341_DS1.pdf
• File Type:
  [PDF - 122.76 KB ]