Allergen Sensitization and Asthma Outcomes Among World Trade Center Rescue and Recovery Workers

Details

• Personal Author:
  Busse P ; Crowley L ; Federman AD ; Ferdermann E ; Harrison D ; Markowitz S ; Rojano B ; West E ; Wisnivesky JP ; Busse P ; Crowley L ; Federman AD ; Ferdermann E ; Harrison D ; Markowitz S ; Rojano B ; West E ; Wisnivesky JP
• Description:
  A large number of World Trade Center (WTC) rescue and recovery workers are affected by asthma. While physical and mental health comorbidities have been associated with poor asthma control in this population, the potential role of allergen sensitization is unknown. This study examined the association of indoor sensitization and exposure as a risk factor for increased asthma morbidity in WTC workers. We used data from a prospective cohort of 331 WTC workers with asthma. Sensitization to indoor allergens was assessed by measurement of antigen-specific serum immunoglobulin E (IgE) levels. We used validated tools to evaluate the exposure to indoor allergens. Asthma morbidity outcomes included level of control (Asthma Control Questionnaire, ACQ), quality of life (Asthma Quality of Life Questionnaire, AQLQ) and acute resource utilization. The prevalence of sensitization to cat, dog, mouse, dust mite, cockroach, and mold allergens were 33%, 21%, 17%, 40%, 17%, and 17%, respectively. Unadjusted and regression analyses showed no significant relationship between sensitization and increased asthma morbidity (p > 0.05 for all comparisons), except for sensitization to Aspergillus Fumigatus, cat and mouse epithelium, which were associated with decreased morbidity. [Description provided by NIOSH]
• Subjects:
  Asthma Emergency Responders Environmental Exposure Hypersensitivity Immune System Men Morbidity Mortality Occupational Health Respiratory System Respiratory Tract Diseases Risk Assessment Risk Factors Safety September 11 Terrorist Attacks Surveys And Questionnaires Women

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• Keywords:
  Allergen Exposure Allergens Asthma Control Asthma Morbidity Asthma Outcomes Asthma Quality Of Life Author Keywords: World Trade Center Bronchial Asthma Exposure Levels Humans Immunoglobulin E Immunoglobulins Indoor Allergens Sensitization Indoor Environments Mini Asthma Quality Of Life Questionnaire Morbidity Rates Mortality Rates Questionnaires Rescue Workers Risk Factors Sensitization Statistical Analysis World Trade Center WTC WTC-related Asthma

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• ISSN:
  1660-4601
• Document Type:
  Text
• Funding:
  Cooperative Agreement ; Contract
• Genre:
  Journal Article ; Journal Article
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH) ; National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health ; Workplace Safety & Health
• Location:
  North America ; North America
• Volume:
  16
• Issue:
  5
• NIOSHTIC Number:
  nn:20054907
• Citation:
  Int J Environ Res Public Health 2019 Mar; 16(5):737
• Contact Point Address:
  Juan P. Wisnivesky, Division of General Internal Medicine, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029
• Email:
  juan.wisnivesky@mssm.edu
• Federal Fiscal Year:
  2019
• Performing Organization:
  Icahn School of Medicine at Mount Sinai, New York
• Peer Reviewed:
  True
• Start Date:
  20120901
• Source Full Name:
  International Journal of Environmental Research and Public Health
• End Date:
  20170831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:b19b02d8263d3579960e09f9ed0f546c0f0b5b00ca10295785b8575e08e7206c5e9b380f7420bf1765c421204075d8bbb96d3daf5c0e433ea1b16480e93497f0
• Download URL:
  https://stacks.cdc.gov/view/cdc/217319/cdc_217319_DS1.pdf
• File Type:
  [PDF - 306.13 KB ]