Ventricular Conduction Abnormalities and Long-Term Air Pollution Exposure in the Multi-Ethnic Study of Atherosclerosis

Details

• Personal Author:
  Kaufman JD ; Neyer J ; Park SK ; Prineas R ; Siscovick D ; Szpiro AA ; Van Hee VC ; Watson K
• Description:
  Objectives: To determine whether long-term air pollution exposure is associated with the prevalence of ventricular electrical activity abnormalities in adults without known cardiovascular disease. Background: Short-term air pollution exposure may affect ventricular repolarization, but knowledge regarding the effects of well-characterized long-term exposures on ventricular electrocardiographic (ECG) abnormalities associated with cardiovascular events is very limited. Methods: 4783 participants free of clinical cardiovascular disease in the Multi-Ethnic Study of Atherosclerosis underwent 12-lead ECG examinations and an extensive air pollution exposure assessment campaign to determine long-term average individual exposure to fine particulate matter (PM2.5) and proximity to major roadways. Ventricular conduction abnormalities including presence of QT prolongation (Rautaharju QTrr criteria) and intraventricular conduction delay (QRS duration > 120 msec, Novacode criteria 3.1, 3.2, or 3.3) were assessed. Logistic regression was used to determine the adjusted relationship between air pollution exposures and these ECG abnormalities. Results: A 10 ug/m3 increase in estimated residential PM2.5 was associated with a significantly increased odds of prevalent QT prolongation (adjusted odds ratio [OR] 1.6, 95% confidence interval [CI]: 1.2 to 2.2, p=0.004) and intraventricular conduction delay (OR 1.7, 95% CI: 1.0 to 2.6, p=0.03). Living near major roadways was not significantly associated with ventricular electrical abnormalities. No significant evidence of effect modification by race, age, gender, other cardiovascular risk factors, or study site was observed. Conclusions: This study suggests that long-term exposure to air pollution may contribute to cardiovascular events via mechanisms involving ventricular conduction abnormalities. [Description provided by NIOSH]
• Subjects:
  Air Pollution Cardiovascular Diseases Cardiovascular System Electrocardiography Epidemiology Occupational Exposure Occupational Health Particulate Matter Public Health Risk Assessment Risk Factors Safety

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• Keywords:
  Air Pollution Author Keywords: QT Interval Cardiovascular Disease Chronic Exposure Health Effects Particulates Public Health Risk Factors
• Publisher:
  American Heart Association
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Abstract or Summary
• Place as Subject:
  California ; Michigan ; North Carolina ; OSHA Region 10 ; OSHA Region 4 ; OSHA Region 5 ; OSHA Region 9 ; Washington
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1
• NIOSHTIC Number:
  nn:20054900
• Citation:
  EPI/NPAM 2011 Conference, March 22-25, 2011, Atlanta, Georgia. Dallas, TX: American Heart Association, 2011 Mar; :1
• Federal Fiscal Year:
  2011
• Performing Organization:
  University of Washington
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  EPI/NPAM 2011 Conference, March 22-25, 2011, Atlanta, Georgia
• End Date:
  20250630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:763c34c58027810924ffe2fe3c73e818015bc770e1d4e024e7c3c6d1f6768dd60126af67315f773cece52656afcb1f3874305920097a266c17d2a0defd04424b
• Download URL:
  https://stacks.cdc.gov/view/cdc/217313/cdc_217313_DS1.pdf
• File Type:
  [PDF - 1.40 MB ]