Differences in Urine Cadmium Associations with Kidney Outcomes Based on Serum Creatinine and Cystatin C

Details

• Personal Author:
  Fadrowski J ; Jaar BG ; Kim N-S ; Lee B-K ; Parsons PJ ; Schwartz BS ; Simon D ; Spector J ; Steuerwald AJ ; Todd AC ; Weaver VM
• Description:
  Cadmium is a well-known nephrotoxicant; chronic exposure increases risk for chronic kidney disease. Recently, however, associations between urine cadmium and higher creatinine-based estimated glomerular filtration rate (eGFR) have been reported. Analyses utilizing alternate biomarkers of kidney function allow evaluation of potential mechanisms for these observations. We compared associations of urine cadmium with kidney function measures based on serum cystatin C to those with serum creatinine in 712 lead workers. Mean (standard deviation) molybdenum-corrected urine cadmium, Modification of Diet in Renal Disease (MDRD) eGFR and multi-variable cystatin C eGFR were 1.02 (0.65) ug/g creatinine, and 97.4 (19.2) and 112.0 (17.7) mL/min/1.73 m2, respectively. The eGFR measures were moderately correlated (rs=0.5; p<0.001). After adjustment, ln (urine cadmium) was not associated with serum cystatin-C-based measures. However, higher ln (urine cadmium) was associated with higher creatinine-based eGFRs including the MDRD and an equation incorporating serum cystatin C and creatinine (beta-coefficient=4.1 mL/min/1.73 m2; 95% confidence interval=1.6, 6.6). Urine creatinine was associated with serum creatinine-based but not cystatin-C-based eGFRs. These results support a biomarker-specific, rather than a kidney function, effect underlying the associations observed between higher urine cadmium and creatinine-based kidney function measures. Given the routine use of serum and urine creatinine in kidney and biomarker research, additional research to elucidate the mechanism(s) for these associations is essential. [Description provided by NIOSH]
• Subjects:
  Biomarkers Cadmium Kidney Diseases Occupational Health Safety Urogenital Diseases Urogenital System
• Keywords:
  Author Keywords: Cadmium Biological Effects Cystatin C Kidney Disorders Kidney Function Nephrotoxicity Serum Creatinine Urine Creatinine
• ISSN:
  0013-9351
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 10 ; Washington
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  111
• Issue:
  8
• NIOSHTIC Number:
  nn:20054856
• Citation:
  Environ Res 2011 Nov; 111(8):1236-1242
• Contact Point Address:
  Division of Occupational and Environmental Health, Department of Environmental Health Sciences, Virginia M. Weaver, Johns Hopkins University Bloomberg School of Public Health, 615N. Wolfe St., Rm. 7041, Baltimore, MD 21205, USA
• Email:
  vweaver@jhsph.edu
• CAS Registry Number:
  Cadmium (CAS RN 7440-43-9) ; Creatinine (CAS RN 60-27-5)
• Federal Fiscal Year:
  2012
• Performing Organization:
  University of Washington
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Environmental Research
• End Date:
  20250630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:5db6ad6a3389fe2909e1b68ab56a069cdceb993281c009dfdd5a178ab9cedbcc1ba00d1daa4878439bb8d69a08cd84a0e619b89d9308547288f8eb0cd7e704df
• Download URL:
  https://stacks.cdc.gov/view/cdc/217274/cdc_217274_DS1.pdf
• File Type:
  [PDF - 225.16 KB ]