Markers of Inflammation and Coagulation After Long-Term Exposure to Coarse Particulate Matter: A Cross-Sectional Analysis from the Multi-Ethnic Study of Atherosclerosis

Details

• Personal Author:
  Adar SD ; Burke GL ; Cushman M ; Daviglus ML ; Diez Roux AV ; D'Souza J ; Jacobs DR Jr. ; Kaufman JD ; Larson TV ; Mendelsohn-Victor K ; Sheppard L ; Szpiro AA ; Thorne PS
• Description:
  Background: Toxicological research suggests that coarse particles (PM10-2.5) are inflammatory, but responses are complex and may be best summarized by multiple inflammatory markers. Few human studies have investigated associations with PM10-2.5 and, of those, none have explored long-term exposures. Here we examine long-term associations with inflammation and coagulation in the Multi-Ethnic Study of Atherosclerosis. Methods: Participants included 3,295 adults (45-84 years of age) from three metropolitan areas. Site-specific spatial models were used to estimate 5-year concentrations of PM10-2.5 mass and copper, zinc, phosphorus, silicon, and endotoxin found in PM10-2.5. Outcomes included interleukin-6, C-reactive protein, fibrinogen, total homocysteine, D-dimer, factor VIII, plasmin-antiplasmin complex, and inflammation and coagulation scores. We used multivariable regression with multiply imputed data to estimate associations while controlling for potential confounders, including co-pollutants such as fine particulate matter. Results: Some limited evidence was found of relationships between inflammation and coagulation and PM10-2.5. Endotoxin was the PM10-2.5 component most strongly associated with inflammation, with an interquartile range (IQR) increase (0.08 EU/m3) associated with 0.15 (95% CI: 0.01, 0.28; p = 0.03) and 0.08 (95% CI: -0.07, 0.23; p = 0.28) higher inflammation scores before and after control for city, respectively. Copper was the component with the strongest association with coagulation, with a 4-ng/m3 increase associated with 0.19 (95% CI: 0.08, 0.30; p = 0.0008) and 0.12 (95% CI: -0.05, 0.30; p = 0.16) unit higher coagulation scores before and after city adjustment, respectively. Conclusions: Our cross-sectional analysis provided some evidence that long-term PM10-2.5 exposure was associated with inflammation and coagulation, but associations were modest and depended on particle composition. [Description provided by NIOSH]
• Subjects:
  Air Pollution Biomarkers Cohort Studies Environmental Monitoring Epidemiology Occupational Health Particulate Matter Safety
• Keywords:
  Air Pollution Air Sampling Biological Monitoring Cohort Studies Particulates
• ISSN:
  0091-6765
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Illinois ; Iowa ; Michigan ; Minnesota ; North Carolina ; OSHA Region 1 ; OSHA Region 10 ; OSHA Region 4 ; OSHA Region 5 ; OSHA Region 7 ; Vermont ; Washington
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  123
• Issue:
  6
• NIOSHTIC Number:
  nn:20054807
• Citation:
  Environ Health Perspect 2015 Jun; 123(6):541-548
• Contact Point Address:
  S.D. Adar, 1415 Washington Heights, SPHII-5539, Ann Arbor, MI 48109 USA
• Email:
  sadar@umich.edu
• Federal Fiscal Year:
  2015
• Performing Organization:
  University of Washington
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Environmental Health Perspectives
• End Date:
  20250630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:5bb50ba7989ac0eed80fa8c641ebc8809ad6cf64cd739fd61c9fbaadf2910465070aedfb13bd3cad51408f7bbd6b9f846b9753e7d3a9b083fcf80ecea6386c6c
• Download URL:
  https://stacks.cdc.gov/view/cdc/217237/cdc_217237_DS1.pdf
• File Type:
  [PDF - 274.38 KB ]